CTR9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0001832Biological processblastocyst growth
GO_0001826Biological processinner cell mass cell differentiation
GO_0001835Biological processblastocyst hatching
GO_0001829Biological processtrophectodermal cell differentiation
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001711Biological processendodermal cell fate commitment
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0019827Biological processstem cell population maintenance
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0016055Biological processWnt signaling pathway
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0016593Cellular componentCdc73/Paf1 complex
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0042169Molecular functionSH2 domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTR9
Protein nameAlternative protein CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)
SynonymsSH2BP1
KIAA0155
DescriptionFUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). .

AccessionsQ6PD62
H0YCE8
ENST00000524523.1
ENST00000361367.7
ENST00000532365.2
L8E8J1
A0A2R8Y3S3