MYT1L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	85% ± 15%	Explore
oligodendrocyte precursor cell	11 studies	36% ± 17%	Explore
GABAergic neuron	10 studies	83% ± 20%	Explore
amacrine cell	7 studies	50% ± 22%	Explore
retinal ganglion cell	7 studies	63% ± 24%	Explore
neuron	6 studies	55% ± 25%	Explore
interneuron	6 studies	87% ± 11%	Explore
retina horizontal cell	6 studies	57% ± 21%	Explore
endothelial cell	4 studies	46% ± 24%	Explore
granule cell	4 studies	71% ± 12%	Explore
microglial cell	4 studies	35% ± 18%	Explore
ON-bipolar cell	4 studies	35% ± 16%	Explore
GABAergic interneuron	3 studies	89% ± 6%	Explore
GABAergic amacrine cell	3 studies	77% ± 9%	Explore
glycinergic amacrine cell	3 studies	69% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	52% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	92%	4942.18	2421 / 2642	50%	2.66	354 / 705
adrenal gland	7%	54.17	17 / 258	62%	2.41	143 / 230
pancreas	0%	1.92	1 / 328	3%	0.10	6 / 178
skin	0%	0.59	2 / 1809	3%	0.07	13 / 472
stomach	0%	0	0 / 359	1%	0.03	4 / 286
eye	0%	0	0 / 0	1%	0.02	1 / 80
bladder	0%	0	0 / 21	1%	0.04	5 / 504
liver	0%	0	0 / 226	1%	0.02	4 / 406
uterus	0%	0	0 / 170	1%	0.02	4 / 459
breast	0%	0	0 / 459	1%	0.02	8 / 1118
lung	0%	0	0 / 578	1%	0.01	6 / 1155
intestine	0%	0	0 / 966	0%	0.01	2 / 527
ovary	0%	0	0 / 180	0%	0.01	1 / 430
thymus	0%	0	0 / 653	0%	0.00	1 / 605
muscle	0%	0.52	1 / 803	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0.00	1 / 901
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
esophagus	0%	0	0 / 1445	0%	0	0 / 183
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030182	Biological process	neuron differentiation
GO_0048665	Biological process	neuron fate specification
GO_0007399	Biological process	nervous system development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048666	Biological process	neuron development
GO_0048663	Biological process	neuron fate commitment
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	MYT1L
Protein name	MYT1L protein (Myelin transcription factor 1 like) Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) Myelin transcription factor 1 like
Synonyms	KIAA1106
Description	FUNCTION: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. .
Accessions	ENST00000648933.1 A0A3B3IS61 A0A2R8YF72 A0A3B3IUE2 ENST00000648366.1 A0A3B3IRK4 ENST00000648316.1 [Q9UL68-4] ENST00000485348.3 ENST00000649663.1 A0A3B3ISN1 A0A3B3IRQ0 ENST00000647755.1 A0A3B3ITJ8 ENST00000407844.6 [Q9UL68-3] ENST00000648928.1 [Q9UL68-4] ENST00000470954.3 A0A3B3IS77 H7BYU4 A0A3B3IS97 ENST00000649840.2 ENST00000399161.8 [Q9UL68-4] ENST00000648885.2 A0A3B3ISG9 ENST00000649810.1 ENST00000490585.2 A0A8I5KQG8 ENST00000647738.2 [Q9UL68-1] A0A3B3IRX0 ENST00000649207.1 [Q9UL68-4] A0A3B3IRM3 A0A3B3ISW5 ENST00000648931.2 A0A3B3IRR4 ENST00000399157.8 A0A3B3IRT9 ENST00000649709.2 Q9UL68 A0A3B3IS14 ENST00000647618.1 A0A3B3IT20 A0A3B3IU66 A0A3B3IRX5 A0A3B3ISU4 ENST00000689939.1 ENST00000648339.1 ENST00000471668.1 ENST00000650399.2 ENST00000648753.2 A0A3B3ISB6 ENST00000650485.2 A0A3B3IRF0 ENST00000649587.1 A0A3B3ISU9 ENST00000649092.2 A0A3B3ITL3 ENST00000648943.2 A0A3B3ITS6 ENST00000648627.1 A0A3B3IU83 ENST00000647694.1 [Q9UL68-1] ENST00000650560.1 A0A3B3ISP2 A0A3B3IS21 A0A3B3IRJ2 A0A3B3ISN3 ENST00000647848.1 ENST00000648430.2 A0A3B3ISI4 ENST00000649313.2 ENST00000602387.6 ENST00000647687.2 ENST00000650081.1 Q49A74 A0A3B3ITT2 ENST00000648665.2 R4GMY9 ENST00000644820.1 ENST00000649741.2 ENST00000650589.2 ENST00000649641.2 ENST00000428368.7 [Q9UL68-1] ENST00000648318.1

MYT1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review