I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 14 studies | 40% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 14 studies | 40% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 34% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 2591.76 | 2607 / 2642 | 81% | 19.03 | 572 / 705 |
| stomach | 37% | 280.02 | 132 / 359 | 7% | 0.80 | 19 / 286 |
| pancreas | 1% | 2.25 | 2 / 328 | 12% | 1.61 | 22 / 178 |
| esophagus | 4% | 11.99 | 55 / 1445 | 3% | 0.19 | 5 / 183 |
| ovary | 1% | 1.11 | 1 / 180 | 4% | 1.87 | 18 / 430 |
| adrenal gland | 0% | 0 | 0 / 258 | 3% | 0.21 | 7 / 230 |
| intestine | 0% | 0 | 0 / 966 | 3% | 0.28 | 14 / 527 |
| kidney | 2% | 7.83 | 2 / 89 | 0% | 0.00 | 1 / 901 |
| lung | 0% | 0 | 0 / 578 | 2% | 0.30 | 27 / 1155 |
| uterus | 0% | 0 | 0 / 170 | 2% | 0.14 | 9 / 459 |
| adipose | 1% | 2.77 | 16 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.15 | 3 / 406 |
| blood vessel | 1% | 1.55 | 7 / 1335 | 0% | 0 | 0 / 0 |
| breast | 0% | 0.92 | 2 / 459 | 0% | 0 | 0 / 1118 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0.01 | 1 / 502 |
| thymus | 0% | 0.28 | 1 / 653 | 0% | 0 | 0 / 605 |
| heart | 0% | 0.38 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0 | 0 / 504 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| skin | 0% | 0 | 0 / 1809 | 0% | 0 | 0 / 472 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010455 | Biological process | positive regulation of cell fate commitment |
| GO_0031641 | Biological process | regulation of myelination |
| GO_0048715 | Biological process | negative regulation of oligodendrocyte differentiation |
| GO_0048663 | Biological process | neuron fate commitment |
| GO_0010454 | Biological process | negative regulation of cell fate commitment |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0050885 | Biological process | neuromuscular process controlling balance |
| GO_0003310 | Biological process | pancreatic A cell differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0022010 | Biological process | central nervous system myelination |
| GO_0030154 | Biological process | cell differentiation |
| GO_0048714 | Biological process | positive regulation of oligodendrocyte differentiation |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| Gene name | NKX6-2 |
| Protein name | Homeobox protein Nkx-6.2 (Homeobox protein NK-6 homolog B) |
| Synonyms | NKX6B GTX |
| Description | FUNCTION: Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. . |
| Accessions | ENST00000368592.8 Q9C056 |
