Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 12 studies | 23% ± 5% | |
| pericyte | 7 studies | 23% ± 5% | |
| endothelial cell | 6 studies | 22% ± 5% | |
| endothelial cell of lymphatic vessel | 5 studies | 19% ± 3% | |
| connective tissue cell | 4 studies | 29% ± 8% | |
| myofibroblast cell | 3 studies | 27% ± 5% |
Insufficient scRNA-seq data for expression of HIC1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3074.10 | 245 / 245 | 96% | 3.85 | 481 / 502 |
| breast | 100% | 2665.66 | 459 / 459 | 95% | 4.58 | 1065 / 1118 |
| lung | 100% | 2130.36 | 576 / 578 | 94% | 4.31 | 1085 / 1155 |
| intestine | 99% | 2036.50 | 960 / 966 | 93% | 4.87 | 492 / 527 |
| esophagus | 93% | 1943.84 | 1348 / 1445 | 99% | 5.92 | 181 / 183 |
| ovary | 100% | 4072.72 | 180 / 180 | 88% | 4.47 | 379 / 430 |
| thymus | 100% | 1929.07 | 650 / 653 | 86% | 6.60 | 521 / 605 |
| stomach | 91% | 1226.54 | 325 / 359 | 95% | 7.64 | 272 / 286 |
| adrenal gland | 100% | 1325.89 | 257 / 258 | 86% | 4.19 | 197 / 230 |
| bladder | 100% | 2519.14 | 21 / 21 | 85% | 3.56 | 427 / 504 |
| uterus | 100% | 4077.42 | 170 / 170 | 82% | 4.34 | 377 / 459 |
| kidney | 97% | 1741.11 | 86 / 89 | 79% | 3.73 | 714 / 901 |
| skin | 89% | 1021.41 | 1618 / 1809 | 83% | 3.34 | 392 / 472 |
| pancreas | 38% | 259.79 | 126 / 328 | 98% | 9.47 | 175 / 178 |
| liver | 56% | 406.29 | 126 / 226 | 66% | 1.82 | 266 / 406 |
| brain | 57% | 336.30 | 1504 / 2642 | 64% | 1.65 | 450 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 4.21 | 29 / 29 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.17 | 1 / 1 |
| adipose | 100% | 3196.34 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 1987.53 | 855 / 861 | 0% | 0 | 0 / 0 |
| spleen | 99% | 1390.84 | 239 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 82% | 924.88 | 1092 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 2.16 | 36 / 45 |
| muscle | 77% | 642.51 | 617 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 50% | 1.00 | 40 / 80 |
| peripheral blood | 31% | 911.05 | 288 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030178 | Biological process | negative regulation of Wnt signaling pathway |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0043517 | Biological process | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0008630 | Biological process | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | HIC1 |
| Protein name | HIC ZBTB transcriptional repressor 1 (Hypermethylated in cancer 1) HIC ZBTB transcriptional repressor 1 Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) Truncated HIC1 protein HIC1 protein |
| Synonyms | ZBTB29 |
| Description | FUNCTION: Transcriptional repressor . Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' . May act as a tumor suppressor . Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses . The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 . In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells . Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes . Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex . Probably represses transcription of ACKR3, FGFBP1 and EFNA1 . . |
| Accessions | ENST00000619757.5 [Q14526-2] A0PJI1 ENST00000571990.1 ENST00000322941.3 [Q14526-1] Q14526 ENST00000576444.1 ENST00000571875.2 Q70SM2 ENST00000574370.1 K7ENQ1 I3L388 V9GYA4 ENST00000399849.4 [Q14526-2] A0MA52 |
