ZHX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045665Biological processnegative regulation of neuron differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006402Biological processmRNA catabolic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0035019Biological processsomatic stem cell population maintenance
GO_0060040Biological processretinal bipolar neuron differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZHX2
Protein nameZinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)
Zinc fingers and homeoboxes 2
SynonymsKIAA0854
RAF
AFR1
DescriptionFUNCTION: Acts as a transcriptional repressor . Represses the promoter activity of the CDC25C gene stimulated by NFYA . May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). .

AccessionsENST00000534247.1
ENST00000314393.6
Q9Y6X8
H0YKA3