Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 36 studies | 41% ± 16% | |
macrophage | 30 studies | 37% ± 21% | |
smooth muscle cell | 29 studies | 47% ± 20% | |
endothelial cell | 27 studies | 34% ± 18% | |
fibroblast | 24 studies | 35% ± 17% | |
microglial cell | 16 studies | 66% ± 17% | |
astrocyte | 13 studies | 47% ± 19% | |
endothelial cell of lymphatic vessel | 12 studies | 28% ± 12% | |
ciliated cell | 11 studies | 33% ± 18% | |
myeloid cell | 10 studies | 43% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 13% | |
type I pneumocyte | 9 studies | 34% ± 13% | |
adipocyte | 9 studies | 41% ± 14% | |
epithelial cell | 8 studies | 45% ± 20% | |
dendritic cell | 8 studies | 33% ± 9% | |
myofibroblast cell | 7 studies | 32% ± 17% | |
retinal ganglion cell | 7 studies | 84% ± 14% | |
connective tissue cell | 7 studies | 34% ± 13% | |
monocyte | 7 studies | 35% ± 12% | |
mast cell | 7 studies | 27% ± 7% | |
classical monocyte | 6 studies | 24% ± 6% | |
basal cell | 6 studies | 31% ± 13% | |
club cell | 6 studies | 34% ± 11% | |
neuron | 6 studies | 49% ± 23% | |
GABAergic neuron | 6 studies | 45% ± 27% | |
capillary endothelial cell | 5 studies | 29% ± 4% | |
retinal bipolar neuron | 5 studies | 40% ± 25% | |
brush cell | 5 studies | 64% ± 18% | |
glutamatergic neuron | 5 studies | 40% ± 21% | |
type II pneumocyte | 5 studies | 26% ± 7% | |
secretory cell | 4 studies | 19% ± 4% | |
non-classical monocyte | 4 studies | 23% ± 5% | |
conventional dendritic cell | 4 studies | 22% ± 7% | |
amacrine cell | 4 studies | 36% ± 23% | |
mononuclear phagocyte | 4 studies | 34% ± 9% | |
OFF-bipolar cell | 4 studies | 69% ± 21% | |
ON-bipolar cell | 4 studies | 48% ± 32% | |
endothelial cell of vascular tree | 4 studies | 28% ± 15% | |
respiratory goblet cell | 4 studies | 30% ± 10% | |
muscle cell | 4 studies | 56% ± 24% | |
glomerular endothelial cell | 3 studies | 34% ± 3% | |
abnormal cell | 3 studies | 36% ± 20% | |
tissue-resident macrophage | 3 studies | 34% ± 14% | |
GABAergic amacrine cell | 3 studies | 45% ± 10% | |
rod bipolar cell | 3 studies | 49% ± 10% | |
hepatocyte | 3 studies | 59% ± 27% | |
ependymal cell | 3 studies | 37% ± 18% | |
adventitial cell | 3 studies | 31% ± 8% | |
alveolar macrophage | 3 studies | 43% ± 11% | |
chondrocyte | 3 studies | 40% ± 11% | |
goblet cell | 3 studies | 31% ± 16% | |
cardiac muscle cell | 3 studies | 22% ± 4% | |
interneuron | 3 studies | 43% ± 19% | |
renal principal cell | 3 studies | 21% ± 6% | |
mucus secreting cell | 3 studies | 31% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4350.53 | 245 / 245 | 99% | 14.18 | 499 / 502 |
ovary | 99% | 1811.92 | 179 / 180 | 97% | 8.51 | 417 / 430 |
thymus | 100% | 5255.96 | 653 / 653 | 96% | 12.58 | 580 / 605 |
esophagus | 95% | 2313.33 | 1372 / 1445 | 99% | 11.83 | 182 / 183 |
lung | 100% | 3053.04 | 577 / 578 | 94% | 7.37 | 1089 / 1155 |
adrenal gland | 100% | 2762.34 | 258 / 258 | 94% | 5.84 | 216 / 230 |
breast | 100% | 2570.68 | 458 / 459 | 92% | 6.83 | 1034 / 1118 |
pancreas | 96% | 1486.20 | 316 / 328 | 95% | 5.68 | 169 / 178 |
bladder | 100% | 4601.57 | 21 / 21 | 90% | 7.13 | 456 / 504 |
stomach | 97% | 1895.16 | 348 / 359 | 91% | 8.11 | 259 / 286 |
kidney | 98% | 1404.13 | 87 / 89 | 89% | 5.78 | 802 / 901 |
intestine | 100% | 3110.59 | 964 / 966 | 84% | 4.98 | 445 / 527 |
uterus | 100% | 3111.00 | 170 / 170 | 80% | 5.48 | 366 / 459 |
skin | 99% | 1985.68 | 1793 / 1809 | 78% | 4.25 | 368 / 472 |
brain | 62% | 731.07 | 1628 / 2642 | 94% | 4.57 | 665 / 705 |
liver | 92% | 1068.83 | 208 / 226 | 58% | 2.22 | 234 / 406 |
blood vessel | 100% | 9062.08 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.10 | 1 / 1 |
adipose | 100% | 3225.68 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 3799.20 | 801 / 803 | 0% | 0 | 0 / 0 |
spleen | 98% | 1132.94 | 235 / 241 | 0% | 0 | 0 / 0 |
heart | 93% | 1466.49 | 805 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 60% | 2.48 | 27 / 45 |
lymph node | 0% | 0 | 0 / 0 | 41% | 1.32 | 12 / 29 |
eye | 0% | 0 | 0 / 0 | 41% | 1.26 | 33 / 80 |
peripheral blood | 17% | 217.62 | 159 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045664 | Biological process | regulation of neuron differentiation |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0071559 | Biological process | response to transforming growth factor beta |
GO_0045785 | Biological process | positive regulation of cell adhesion |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_1904059 | Biological process | regulation of locomotor rhythm |
GO_0032922 | Biological process | circadian regulation of gene expression |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0007517 | Biological process | muscle organ development |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016604 | Cellular component | nuclear body |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ZFHX3 |
Protein name | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) ZFHX3 protein |
Synonyms | C16orf47 ATBF1 |
Description | FUNCTION: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 . Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression . Down-regulates the MUC5AC promoter in gastric cancer . In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation . Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells . . |
Accessions | ENST00000397992.5 [Q15911-2] ENST00000641206.2 [Q15911-1] ENST00000268489.10 [Q15911-1] Q15911 Q8N2Y6 |