ZFHX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071559Biological processresponse to transforming growth factor beta
GO_0045785Biological processpositive regulation of cell adhesion
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1904059Biological processregulation of locomotor rhythm
GO_0032922Biological processcircadian regulation of gene expression
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007517Biological processmuscle organ development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFHX3
Protein nameZinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)
ZFHX3 protein
SynonymsC16orf47
ATBF1
DescriptionFUNCTION: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 . Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression . Down-regulates the MUC5AC promoter in gastric cancer . In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation . Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells . .

AccessionsENST00000397992.5 [Q15911-2]
ENST00000641206.2 [Q15911-1]
ENST00000268489.10 [Q15911-1]
Q15911
Q8N2Y6