SRY | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SRY at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	66%	57.42	1198 / 1809	2%	0.05	9 / 472
adrenal gland	45%	10.36	116 / 258	3%	0.13	7 / 230
esophagus	24%	7.40	348 / 1445	15%	0.41	27 / 183
tonsil	0%	0	0 / 0	31%	0.93	14 / 45
adipose	25%	5.42	300 / 1204	0%	0	0 / 0
breast	18%	3.02	82 / 459	0%	0	0 / 1118
brain	6%	1.55	165 / 2642	11%	0.43	76 / 705
bladder	5%	1.05	1 / 21	6%	0.23	29 / 504
prostate	10%	1.14	24 / 245	0%	0.00	1 / 502
lung	2%	0.31	12 / 578	6%	0.20	72 / 1155
pancreas	2%	0.29	8 / 328	5%	0.10	9 / 178
thymus	1%	0.20	8 / 653	6%	0.42	37 / 605
blood vessel	7%	1.02	92 / 1335	0%	0	0 / 0
spleen	5%	0.81	13 / 241	0%	0	0 / 0
intestine	1%	0.09	7 / 966	2%	0.03	8 / 527
muscle	2%	0.28	17 / 803	0%	0	0 / 0
stomach	1%	0.09	2 / 359	1%	0.01	2 / 286
uterus	0%	0	0 / 170	1%	0.02	5 / 459
liver	0%	0	0 / 226	1%	0.02	3 / 406
peripheral blood	0%	0.04	3 / 929	0%	0	0 / 0
heart	0%	0.03	2 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0	0 / 901
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030238	Biological process	male sex determination
GO_0007548	Biological process	sex differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030182	Biological process	neuron differentiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_2000020	Biological process	positive regulation of male gonad development
GO_0007420	Biological process	brain development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SRY
Protein name	Mutant SRY Truncated sex-determining region Y protein Sex determining region Y Sex-determining region Y protein Sex-determining region Y protein (Testis-determining factor) SRY
Synonyms	hCG_1733150 TDF
Description	FUNCTION: Transcriptional regulator that controls a genetic switch in male development . It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells . Involved in different aspects of gene regulation including promoter activation or repression . Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' . SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending . Also involved in pre-mRNA splicing . In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. . FUNCTION: Transcriptional regulator that controls a genetic switch in male development. .
Accessions	A0A411ELE5 A0A1Z3FT70 Q7Z5C6 A0A411ELD1 A0A411ELS2 Q52MY2 A0A411ELQ6 A0A411ELP6 Q52MX8 Q8WZ47 U5XKX7 U5XMN5 U5XN82 D0VTX0 D9J2M1 D6QZA3 A0A411ELD0 D9J2M3 D9J2M2 A7WPU8 D0VTX3 A0A411ELH3 Q7Z5C5 ENST00000383070.2 Q6J4I5 Q7Z5C4 Q7Z5C8 A7WPV0 A7WPU9 U5XN77 Q52MY0 D1H0M5 A0A411ELR1 A7WPU7 Q52MX9 U5XKY1 Q7Z5C7 D0VTX2 H9U933 D0VTX1 H9U923 A0A411ELP9 D6QZA4 Q52MX7 Q52MY1 A0A411ELN9 D9J2M4 Q6J0W4 A0A411ELD8 A7WPV2 Q05066 U5XK65 Q52MY3 A0A411ELF4 Q6PWT1 U5XK60 H9U921 D9J2M0 Q6J4J1 A0A411ELP4 Q6J0W5

SRY report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review