DMRT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DMRT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DMRT1 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0030238Biological processmale sex determination
GO_0002176Biological processmale germ cell proliferation
GO_0060009Biological processSertoli cell development
GO_0007548Biological processsex differentiation
GO_1900107Biological processregulation of nodal signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0046661Biological processmale sex differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060008Biological processSertoli cell differentiation
GO_0048599Biological processoocyte development
GO_0060903Biological processpositive regulation of meiosis I
GO_0045835Biological processnegative regulation of meiotic nuclear division
GO_0035556Biological processintracellular signal transduction
GO_2000020Biological processpositive regulation of male gonad development
GO_0000902Biological processcell morphogenesis
GO_0008354Biological processgerm cell migration
GO_0007127Biological processmeiosis I
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001674Cellular componentfemale germ cell nucleus
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDMRT1
Protein nameDoublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
Doublesex and mab-3 related transcription factor 1
SynonymsDMT1
DescriptionFUNCTION: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). .

AccessionsQ9Y5R6
ENST00000382276.8 [Q9Y5R6-1]
H3BN61
ENST00000569227.1