EN1 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EN1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	1025.89	1809 / 1809	65%	3.14	306 / 472
breast	78%	196.56	360 / 459	79%	18.70	888 / 1118
ureter	0%	0	0 / 0	100%	16.98	1 / 1
muscle	99%	611.40	795 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	1.74	22 / 29
adipose	64%	264.81	769 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	62%	3.87	28 / 45
esophagus	0%	0.48	5 / 1445	45%	13.03	83 / 183
uterus	0%	0	0 / 170	45%	5.78	208 / 459
brain	5%	48.64	126 / 2642	39%	4.44	277 / 705
adrenal gland	5%	8.01	12 / 258	30%	1.78	68 / 230
lung	0%	0	0 / 578	27%	2.54	307 / 1155
bladder	0%	0	0 / 21	25%	2.59	126 / 504
pancreas	0%	0	0 / 328	20%	0.90	35 / 178
kidney	0%	0	0 / 89	12%	0.70	110 / 901
blood vessel	11%	44.89	141 / 1335	0%	0	0 / 0
ovary	0%	0	0 / 180	10%	0.24	42 / 430
liver	0%	0	0 / 226	7%	0.47	27 / 406
intestine	0%	0	0 / 966	7%	0.28	35 / 527
stomach	0%	0	0 / 359	5%	0.24	15 / 286
thymus	1%	1.10	5 / 653	4%	0.15	27 / 605
prostate	0%	0	0 / 245	3%	0.07	13 / 502
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0042756	Biological process	drinking behavior
GO_0009954	Biological process	proximal/distal pattern formation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0008344	Biological process	adult locomotory behavior
GO_0035264	Biological process	multicellular organism growth
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030917	Biological process	midbrain-hindbrain boundary development
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0030182	Biological process	neuron differentiation
GO_0042220	Biological process	response to cocaine
GO_0048666	Biological process	neuron development
GO_0043473	Biological process	pigmentation
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0021549	Biological process	cerebellum development
GO_0001501	Biological process	skeletal system development
GO_0035176	Biological process	social behavior
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0061743	Biological process	motor learning
GO_0030901	Biological process	midbrain development
GO_1990403	Biological process	embryonic brain development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding

Gene name	EN1
Protein name	Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Synonyms
Description	FUNCTION: Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb. .
Accessions	Q05925 ENST00000295206.7

EN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review