HESX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HESX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HESX1 at tissue level.

III. Associated gene sets

GO_0008406Biological processgonad development
GO_0045995Biological processregulation of embryonic development
GO_0030916Biological processotic vesicle formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071276Biological processcellular response to cadmium ion
GO_0035264Biological processmulticellular organism growth
GO_0030878Biological processthyroid gland development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0043584Biological processnose development
GO_0070371Biological processERK1 and ERK2 cascade
GO_0019827Biological processstem cell population maintenance
GO_0007420Biological processbrain development
GO_0043010Biological processcamera-type eye development
GO_0010467Biological processgene expression
GO_0021983Biological processpituitary gland development
GO_0048863Biological processstem cell differentiation
GO_0048861Biological processleukemia inhibitory factor signaling pathway
GO_0048853Biological processforebrain morphogenesis
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHESX1
Protein nameHomeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf)
Homeobox expressed in ES cells 1
HESX homeobox 1
SynonymsHANF
DescriptionFUNCTION: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. .

AccessionsJ3KR67
C9J0A9
Q9UBX0
ENST00000295934.8
ENST00000647958.1
ENST00000473921.2
ENST00000495160.2