MAGED1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0042752Biological processregulation of circadian rhythm
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0034504Biological processprotein localization to nucleus
GO_0006355Biological processregulation of DNA-templated transcription
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAGED1
Protein nameMelanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)
SynonymsPRO2292
NRAGE
PP2250
DescriptionFUNCTION: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. .

AccessionsENST00000375722.5 [Q9Y5V3-1]
ENST00000326587.12 [Q9Y5V3-1]
ENST00000375695.2 [Q9Y5V3-2]
Q9Y5V3
ENST00000375772.7 [Q9Y5V3-1]