UHRF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UHRF1 at tissue level.

III. Associated gene sets

GO_2000373Biological processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO_0016567Biological processprotein ubiquitination
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051865Biological processprotein autoubiquitination
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031507Biological processheterochromatin formation
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0090307Biological processmitotic spindle assembly
GO_0035825Biological processhomologous recombination
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000792Cellular componentheterochromatin
GO_0005657Cellular componentreplication fork
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0000785Cellular componentchromatin
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0062072Molecular functionH3K9me3 modified histone binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0042393Molecular functionhistone binding
GO_0003676Molecular functionnucleic acid binding
GO_0044729Molecular functionhemi-methylated DNA-binding
GO_0141055Molecular functionhistone H3 ubiquitin ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0008327Molecular functionmethyl-CpG binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0140612Molecular functionDNA damage sensor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUHRF1
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase UHRF (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF) (Ubiquitin-like PHD and RING finger domain-containing protein) (Ubiquitin-like-containing PHD and RING finger domains protein)
Alternative protein UHRF1
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
SynonymsRNF106
ICBP90
hCG_23497
NP95
DescriptionFUNCTION: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle . .

FUNCTION: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications. .

FUNCTION: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications. .

FUNCTION: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications. .

AccessionsA0A087WTW0
ENST00000622802.4
ENST00000620565.4
ENST00000650932.1 [Q96T88-1]
A0A087WVR3
ENST00000615884.4 [Q96T88-1]
ENST00000613817.4
L8ECE3
A0A087WWG9
ENST00000616255.1 [Q96T88-1]
Q96T88
ENST00000624301.3 [Q96T88-1]
ENST00000612630.4 [Q96T88-1]