I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| interneuron | 4 studies | 34% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| interneuron | 4 studies | 34% ± 13% |
Insufficient scRNA-seq data for expression of DLX1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 71% | 527.21 | 1887 / 2642 | 70% | 7.15 | 490 / 705 |
| skin | 64% | 122.95 | 1161 / 1809 | 75% | 13.59 | 356 / 472 |
| thymus | 98% | 193.49 | 642 / 653 | 23% | 0.57 | 139 / 605 |
| prostate | 23% | 15.86 | 56 / 245 | 91% | 39.32 | 459 / 502 |
| adrenal gland | 20% | 28.05 | 51 / 258 | 67% | 24.51 | 154 / 230 |
| intestine | 70% | 72.38 | 681 / 966 | 6% | 0.26 | 31 / 527 |
| esophagus | 33% | 20.20 | 478 / 1445 | 34% | 1.38 | 62 / 183 |
| bladder | 33% | 14.29 | 7 / 21 | 13% | 0.68 | 63 / 504 |
| breast | 9% | 7.47 | 43 / 459 | 27% | 3.76 | 302 / 1118 |
| stomach | 26% | 18.58 | 95 / 359 | 6% | 0.30 | 16 / 286 |
| uterus | 9% | 6.64 | 15 / 170 | 22% | 3.63 | 101 / 459 |
| blood vessel | 30% | 31.83 | 402 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 0.70 | 12 / 45 |
| kidney | 3% | 1.19 | 3 / 89 | 20% | 0.49 | 177 / 901 |
| lung | 0% | 0.12 | 2 / 578 | 22% | 1.24 | 256 / 1155 |
| heart | 15% | 8.12 | 128 / 861 | 0% | 0 | 0 / 0 |
| ovary | 7% | 3.33 | 13 / 180 | 4% | 0.69 | 18 / 430 |
| adipose | 7% | 5.06 | 89 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 6% | 3.16 | 51 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 6% | 0.45 | 25 / 406 |
| pancreas | 0% | 0.13 | 1 / 328 | 5% | 0.08 | 9 / 178 |
| peripheral blood | 4% | 2.43 | 36 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0009790 | Biological process | embryo development |
| GO_0048715 | Biological process | negative regulation of oligodendrocyte differentiation |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0021766 | Biological process | hippocampus development |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0021879 | Biological process | forebrain neuron differentiation |
| GO_1903845 | Biological process | negative regulation of cellular response to transforming growth factor beta stimulus |
| GO_1902871 | Biological process | positive regulation of amacrine cell differentiation |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0021544 | Biological process | subpallium development |
| GO_0046533 | Biological process | negative regulation of photoreceptor cell differentiation |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0048706 | Biological process | embryonic skeletal system development |
| GO_0030154 | Biological process | cell differentiation |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0014016 | Biological process | neuroblast differentiation |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0021893 | Biological process | cerebral cortex GABAergic interneuron fate commitment |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003682 | Molecular function | chromatin binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DLX1 |
| Protein name | cDNA FLJ76107, highly similar to Homo sapiens distal-less homeo box 1 (DLX1), mRNA Distal-less homeobox 1 Homeobox protein DLX-1 Distal-less homeobox 1 isoform A |
| Synonyms | |
| Description | FUNCTION: Plays a role as a transcriptional activator or repressor . Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation . Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). . |
| Accessions | P56177 F8VXJ2 Q53SU3 ENST00000709712.1 [P56177-1] ENST00000709713.1 [P56177-2] ENST00000469444.6 ENST00000361609.4 ENST00000361725.5 [P56177-1] X5D2F9 J3KP55 ENST00000341900.6 [P56177-2] |
