MMP12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMP12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP12 at tissue level.

III. Associated gene sets

GO_0060054Biological processpositive regulation of epithelial cell proliferation involved in wound healing
GO_0048286Biological processlung alveolus development
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0060435Biological processbronchiole development
GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_1904645Biological processresponse to amyloid-beta
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030574Biological processcollagen catabolic process
GO_1904905Biological processnegative regulation of endothelial cell-matrix adhesion via fibronectin
GO_0098586Biological processcellular response to virus
GO_0006508Biological processproteolysis
GO_0006606Biological processprotein import into nucleus
GO_0060309Biological processelastin catabolic process
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0050691Biological processregulation of defense response to virus by host
GO_0035313Biological processwound healing, spreading of epidermal cells
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005518Molecular functioncollagen binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameMMP12
Protein nameMacrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
SynonymsHME
DescriptionFUNCTION: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

AccessionsENST00000571244.3
P39900