WWC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0046621Biological processnegative regulation of organ growth
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035330Biological processregulation of hippo signaling
GO_0016477Biological processcell migration
GO_0035329Biological processhippo signaling
GO_0006355Biological processregulation of DNA-templated transcription
GO_0035331Biological processnegative regulation of hippo signaling
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019900Molecular functionkinase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameWWC2
Protein nameWW and C2 domain containing 2
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
SynonymsBOMB
DescriptionFUNCTION: Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. .

AccessionsENST00000508747.1 [Q6AWC2-7]
ENST00000448232.6 [Q6AWC2-6]
Q6AWC2
ENST00000438543.5 [Q6AWC2-5]
ENST00000427431.5
F8WET3
ENST00000403733.8 [Q6AWC2-1]
D6R9P8
ENST00000504005.5 [Q6AWC2-3]
ENST00000508614.5
ENST00000513834.5 [Q6AWC2-4]