Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 28 studies | 37% ± 19% | |
| type I pneumocyte | 12 studies | 51% ± 20% | |
| microglial cell | 10 studies | 31% ± 11% | |
| fibroblast | 10 studies | 31% ± 9% | |
| adipocyte | 8 studies | 29% ± 9% | |
| type II pneumocyte | 7 studies | 32% ± 13% | |
| pericyte | 7 studies | 27% ± 9% | |
| glutamatergic neuron | 7 studies | 40% ± 22% | |
| macrophage | 7 studies | 34% ± 9% | |
| epithelial cell | 7 studies | 29% ± 11% | |
| astrocyte | 6 studies | 30% ± 16% | |
| oligodendrocyte precursor cell | 6 studies | 27% ± 10% | |
| retinal cone cell | 5 studies | 39% ± 14% | |
| endothelial cell of lymphatic vessel | 5 studies | 32% ± 9% | |
| GABAergic neuron | 5 studies | 53% ± 19% | |
| club cell | 5 studies | 27% ± 12% | |
| smooth muscle cell | 5 studies | 25% ± 3% | |
| oligodendrocyte | 5 studies | 29% ± 11% | |
| retinal pigment epithelial cell | 4 studies | 33% ± 12% | |
| cardiac muscle cell | 4 studies | 25% ± 2% | |
| mesothelial cell | 4 studies | 38% ± 20% | |
| retinal rod cell | 4 studies | 43% ± 9% | |
| GABAergic interneuron | 3 studies | 24% ± 2% | |
| endothelial cell of artery | 3 studies | 20% ± 1% | |
| vein endothelial cell | 3 studies | 27% ± 11% | |
| endothelial cell of vascular tree | 3 studies | 32% ± 20% | |
| hepatocyte | 3 studies | 66% ± 18% | |
| connective tissue cell | 3 studies | 23% ± 3% | |
| capillary endothelial cell | 3 studies | 30% ± 11% | |
| interneuron | 3 studies | 63% ± 14% | |
| kidney loop of Henle epithelial cell | 3 studies | 36% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2243.17 | 89 / 89 | 96% | 15.21 | 868 / 901 |
| pancreas | 100% | 1258.03 | 327 / 328 | 93% | 7.11 | 165 / 178 |
| lung | 100% | 4093.99 | 578 / 578 | 92% | 7.70 | 1060 / 1155 |
| esophagus | 100% | 1718.01 | 1442 / 1445 | 92% | 7.49 | 168 / 183 |
| breast | 100% | 2180.85 | 459 / 459 | 91% | 10.87 | 1013 / 1118 |
| skin | 99% | 2035.10 | 1792 / 1809 | 90% | 8.97 | 426 / 472 |
| thymus | 100% | 3295.99 | 653 / 653 | 88% | 14.30 | 535 / 605 |
| brain | 92% | 899.48 | 2438 / 2642 | 94% | 5.86 | 664 / 705 |
| prostate | 100% | 1729.61 | 244 / 245 | 85% | 5.95 | 429 / 502 |
| liver | 100% | 1914.39 | 226 / 226 | 81% | 6.12 | 329 / 406 |
| ovary | 100% | 2492.79 | 180 / 180 | 80% | 4.29 | 345 / 430 |
| stomach | 100% | 1481.79 | 359 / 359 | 76% | 4.92 | 216 / 286 |
| uterus | 100% | 2324.77 | 170 / 170 | 70% | 4.12 | 322 / 459 |
| bladder | 100% | 1802.43 | 21 / 21 | 69% | 3.69 | 349 / 504 |
| intestine | 91% | 1606.69 | 883 / 966 | 58% | 3.30 | 307 / 527 |
| adrenal gland | 100% | 1360.64 | 258 / 258 | 43% | 2.32 | 100 / 230 |
| adipose | 100% | 2527.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2531.56 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1644.37 | 846 / 861 | 0% | 0 | 0 / 0 |
| spleen | 96% | 845.83 | 232 / 241 | 0% | 0 | 0 / 0 |
| muscle | 87% | 606.44 | 700 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 73% | 5.16 | 58 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 3.26 | 29 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.23 | 3 / 29 |
| peripheral blood | 0% | 1.61 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0046621 | Biological process | negative regulation of organ growth |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0035330 | Biological process | regulation of hippo signaling |
| GO_0016477 | Biological process | cell migration |
| GO_0035329 | Biological process | hippo signaling |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0035331 | Biological process | negative regulation of hippo signaling |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0019900 | Molecular function | kinase binding |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0060090 | Molecular function | molecular adaptor activity |
| Gene name | WWC2 |
| Protein name | WW and C2 domain containing 2 Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) |
| Synonyms | BOMB |
| Description | FUNCTION: Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. . |
| Accessions | ENST00000508747.1 [Q6AWC2-7] ENST00000448232.6 [Q6AWC2-6] Q6AWC2 ENST00000438543.5 [Q6AWC2-5] ENST00000427431.5 F8WET3 ENST00000403733.8 [Q6AWC2-1] D6R9P8 ENST00000504005.5 [Q6AWC2-3] ENST00000508614.5 ENST00000513834.5 [Q6AWC2-4] |