FOXA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032355Biological processresponse to estradiol
GO_0007224Biological processsmoothened signaling pathway
GO_0007219Biological processNotch signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_1902691Biological processrespiratory basal cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060743Biological processepithelial cell maturation involved in prostate gland development
GO_0060441Biological processepithelial tube branching involved in lung morphogenesis
GO_1904340Biological processpositive regulation of dopaminergic neuron differentiation
GO_0048665Biological processneuron fate specification
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0071542Biological processdopaminergic neuron differentiation
GO_0033148Biological processpositive regulation of intracellular estrogen receptor signaling pathway
GO_0021904Biological processdorsal/ventral neural tube patterning
GO_0006338Biological processchromatin remodeling
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0060741Biological processprostate gland stromal morphogenesis
GO_0060740Biological processprostate gland epithelium morphogenesis
GO_0060528Biological processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO_0048646Biological processanatomical structure formation involved in morphogenesis
GO_0030154Biological processcell differentiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_2000049Biological processpositive regulation of cell-cell adhesion mediated by cadherin
GO_0009653Biological processanatomical structure morphogenesis
GO_0061144Biological processalveolar secondary septum development
GO_0060739Biological processmesenchymal-epithelial cell signaling involved in prostate gland development
GO_0043065Biological processpositive regulation of apoptotic process
GO_0042445Biological processhormone metabolic process
GO_0060487Biological processlung epithelial cell differentiation
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005902Cellular componentmicrovillus
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0019904Molecular functionprotein domain specific binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXA1
Protein nameForkhead box A1
Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)
SynonymsHNF3A
TCF3A
DescriptionFUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. .

AccessionsG3V4B9
ENST00000553751.1
P55317
ENST00000250448.5 [P55317-1]