CHD3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	14 studies	23% ± 7%	Explore
regulatory T cell	14 studies	21% ± 4%	Explore
natural killer cell	13 studies	21% ± 4%	Explore
T cell	11 studies	22% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	24% ± 9%	Explore
fibroblast	10 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	10 studies	20% ± 6%	Explore
basal cell	9 studies	33% ± 13%	Explore
endothelial cell	9 studies	31% ± 13%	Explore
smooth muscle cell	8 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	27% ± 9%	Explore
neuron	8 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 3%	Explore
glutamatergic neuron	7 studies	36% ± 14%	Explore
interneuron	7 studies	30% ± 11%	Explore
gamma-delta T cell	7 studies	25% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	26% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
epithelial cell	6 studies	41% ± 20%	Explore
club cell	5 studies	29% ± 5%	Explore
secretory cell	5 studies	34% ± 10%	Explore
myofibroblast cell	5 studies	23% ± 6%	Explore
mucosal invariant T cell	5 studies	18% ± 2%	Explore
dendritic cell	5 studies	28% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
GABAergic neuron	5 studies	35% ± 7%	Explore
respiratory goblet cell	4 studies	30% ± 9%	Explore
mature NK T cell	4 studies	18% ± 3%	Explore
connective tissue cell	4 studies	24% ± 9%	Explore
ciliated cell	4 studies	32% ± 9%	Explore
lymphocyte	4 studies	27% ± 7%	Explore
leukocyte	3 studies	19% ± 3%	Explore
classical monocyte	3 studies	24% ± 6%	Explore
macrophage	3 studies	24% ± 5%	Explore
progenitor cell	3 studies	23% ± 8%	Explore
retinal ganglion cell	3 studies	39% ± 16%	Explore
type II pneumocyte	3 studies	23% ± 6%	Explore
amacrine cell	3 studies	21% ± 6%	Explore
T follicular helper cell	3 studies	24% ± 3%	Explore
transit amplifying cell	3 studies	30% ± 15%	Explore
brush cell	3 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 2%	Explore
enteroendocrine cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	29% ± 11%	Explore
peripheral blood	7 studies	20% ± 6%	Explore
lung	6 studies	22% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	28302.01	245 / 245	100%	107.14	502 / 502
breast	100%	11299.64	459 / 459	100%	76.12	1116 / 1118
uterus	100%	25883.45	170 / 170	100%	73.39	458 / 459
pancreas	100%	7549.20	327 / 328	100%	66.68	178 / 178
skin	100%	10801.59	1808 / 1809	100%	66.81	470 / 472
thymus	100%	18105.96	653 / 653	99%	64.35	599 / 605
esophagus	100%	12961.21	1445 / 1445	99%	62.14	181 / 183
ovary	100%	20175.16	180 / 180	99%	61.99	424 / 430
lung	100%	12331.72	578 / 578	98%	55.84	1127 / 1155
bladder	100%	15581.05	21 / 21	97%	59.03	488 / 504
adrenal gland	100%	11715.49	258 / 258	95%	56.49	218 / 230
stomach	100%	11473.61	359 / 359	93%	36.54	267 / 286
brain	96%	11370.88	2536 / 2642	97%	55.87	686 / 705
intestine	100%	17306.49	966 / 966	93%	32.83	490 / 527
kidney	100%	12128.83	89 / 89	91%	33.55	821 / 901
adipose	100%	9261.34	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	94.27	80 / 80
lymph node	0%	0	0 / 0	100%	59.99	29 / 29
spleen	100%	12097.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	74.77	45 / 45
ureter	0%	0	0 / 0	100%	18.46	1 / 1
blood vessel	99%	8448.67	1326 / 1335	0%	0	0 / 0
peripheral blood	97%	8912.50	897 / 929	0%	0	0 / 0
heart	81%	3935.27	699 / 861	0%	0	0 / 0
liver	6%	202.97	14 / 226	30%	10.91	121 / 406
muscle	12%	330.72	94 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000736	Biological process	regulation of stem cell differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0007098	Biological process	centrosome cycle
GO_0042659	Biological process	regulation of cell fate specification
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0007051	Biological process	spindle organization
GO_0005730	Cellular component	nucleolus
GO_0034451	Cellular component	centriolar satellite
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0016605	Cellular component	PML body
GO_0005737	Cellular component	cytoplasm
GO_0016581	Cellular component	NuRD complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0004386	Molecular function	helicase activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0008270	Molecular function	zinc ion binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0140658	Molecular function	ATP-dependent chromatin remodeler activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	CHD3
Protein name	Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) CHD3 protein Chromodomain helicase DNA binding protein 3 DNA helicase (EC 3.6.4.12)
Synonyms
Description	FUNCTION: ATP-dependent helicase that binds and distorts nucleosomal DNA . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Involved in transcriptional repression as part of the NuRD complex . Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity . .
Accessions	A0A8V8TR54 A0A5F9ZHX5 ENST00000573936.5 H7C0J3 I3L229 ENST00000439235.5 Q2TAZ1 ENST00000358181.8 [Q12873-2] A0A5F9ZHM2 ENST00000330494.12 [Q12873-1] ENST00000470531.5 K7EPV1 H7C2H0 ENST00000700753.1 ENST00000672274.1 ENST00000672838.1 ENST00000449744.1 ENST00000380358.9 [Q12873-3] H7C3H7 I3L1I4 ENST00000452447.1 Q12873 ENST00000571249.1

CHD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review