RBBP4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	30% ± 10%	Explore
B cell	26 studies	31% ± 11%	Explore
endothelial cell	22 studies	29% ± 12%	Explore
CD8-positive, alpha-beta T cell	21 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	21 studies	28% ± 11%	Explore
fibroblast	21 studies	27% ± 11%	Explore
T cell	20 studies	27% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	38% ± 14%	Explore
regulatory T cell	18 studies	27% ± 7%	Explore
memory B cell	16 studies	25% ± 7%	Explore
naive B cell	16 studies	24% ± 6%	Explore
pericyte	16 studies	27% ± 9%	Explore
smooth muscle cell	15 studies	25% ± 8%	Explore
macrophage	15 studies	25% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 9%	Explore
conventional dendritic cell	14 studies	28% ± 15%	Explore
mature NK T cell	14 studies	25% ± 7%	Explore
gamma-delta T cell	14 studies	29% ± 15%	Explore
plasma cell	13 studies	32% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	28% ± 8%	Explore
classical monocyte	12 studies	23% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	27% ± 8%	Explore
non-classical monocyte	11 studies	25% ± 10%	Explore
connective tissue cell	11 studies	33% ± 16%	Explore
epithelial cell	11 studies	40% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 9%	Explore
myofibroblast cell	10 studies	32% ± 13%	Explore
monocyte	10 studies	21% ± 5%	Explore
oligodendrocyte precursor cell	10 studies	31% ± 12%	Explore
mucosal invariant T cell	10 studies	26% ± 7%	Explore
astrocyte	10 studies	29% ± 11%	Explore
endothelial cell of lymphatic vessel	9 studies	22% ± 6%	Explore
plasmablast	9 studies	42% ± 22%	Explore
basal cell	9 studies	31% ± 15%	Explore
abnormal cell	9 studies	30% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 6%	Explore
ciliated cell	8 studies	28% ± 11%	Explore
oligodendrocyte	8 studies	26% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
progenitor cell	7 studies	31% ± 11%	Explore
mesothelial cell	7 studies	34% ± 17%	Explore
neuron	7 studies	40% ± 14%	Explore
T follicular helper cell	7 studies	21% ± 4%	Explore
GABAergic neuron	7 studies	36% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	34% ± 15%	Explore
capillary endothelial cell	6 studies	21% ± 8%	Explore
endothelial cell of artery	6 studies	17% ± 1%	Explore
interneuron	6 studies	36% ± 18%	Explore
microglial cell	6 studies	23% ± 7%	Explore
dendritic cell	6 studies	39% ± 18%	Explore
precursor B cell	6 studies	42% ± 13%	Explore
mast cell	6 studies	20% ± 4%	Explore
hematopoietic precursor cell	5 studies	40% ± 14%	Explore
leukocyte	5 studies	26% ± 7%	Explore
vein endothelial cell	5 studies	22% ± 5%	Explore
transit amplifying cell	5 studies	28% ± 16%	Explore
glutamatergic neuron	5 studies	50% ± 20%	Explore
hematopoietic stem cell	5 studies	37% ± 15%	Explore
lymphocyte	5 studies	29% ± 10%	Explore
pro-B cell	5 studies	46% ± 7%	Explore
myeloid cell	5 studies	25% ± 8%	Explore
brush cell	5 studies	29% ± 14%	Explore
club cell	5 studies	24% ± 7%	Explore
type I pneumocyte	5 studies	25% ± 9%	Explore
amacrine cell	5 studies	29% ± 13%	Explore
endothelial cell of vascular tree	5 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 7%	Explore
innate lymphoid cell	5 studies	24% ± 5%	Explore
goblet cell	5 studies	29% ± 11%	Explore
secretory cell	4 studies	22% ± 9%	Explore
exhausted T cell	4 studies	36% ± 3%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 3%	Explore
retinal bipolar neuron	4 studies	31% ± 12%	Explore
immature B cell	4 studies	29% ± 8%	Explore
type II pneumocyte	4 studies	29% ± 10%	Explore
retina horizontal cell	4 studies	31% ± 10%	Explore
retinal cone cell	4 studies	37% ± 14%	Explore
retinal rod cell	4 studies	22% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	32% ± 15%	Explore
respiratory goblet cell	3 studies	22% ± 10%	Explore
type B pancreatic cell	3 studies	29% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	47% ± 18%	Explore
epithelial cell of proximal tubule	3 studies	22% ± 9%	Explore
neural crest cell	3 studies	40% ± 10%	Explore
glial cell	3 studies	37% ± 19%	Explore
erythroblast	3 studies	57% ± 12%	Explore
precursor cell	3 studies	37% ± 16%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
OFF-bipolar cell	3 studies	22% ± 6%	Explore
ON-bipolar cell	3 studies	22% ± 5%	Explore
glycinergic amacrine cell	3 studies	19% ± 2%	Explore
rod bipolar cell	3 studies	30% ± 6%	Explore
germinal center B cell	3 studies	48% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 30%	Explore
intestinal crypt stem cell	3 studies	24% ± 4%	Explore
erythrocyte	3 studies	45% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 14%	Explore
adipocyte	3 studies	18% ± 3%	Explore
T-helper 1 cell	3 studies	27% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	27% ± 9%	Explore
double negative thymocyte	3 studies	47% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	28% ± 8%	Explore
brain	12 studies	31% ± 15%	Explore
lung	10 studies	28% ± 10%	Explore
eye	8 studies	25% ± 10%	Explore
intestine	7 studies	26% ± 12%	Explore
kidney	6 studies	26% ± 9%	Explore
lymph node	5 studies	28% ± 5%	Explore
bone marrow	4 studies	21% ± 3%	Explore
uterus	3 studies	29% ± 13%	Explore
adipose	3 studies	20% ± 3%	Explore
liver	3 studies	41% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6205.42	1445 / 1445	100%	40.44	183 / 183
lung	100%	6125.02	578 / 578	100%	40.16	1155 / 1155
ovary	100%	8544.26	180 / 180	100%	48.55	430 / 430
stomach	100%	5790.48	359 / 359	100%	36.04	286 / 286
brain	100%	5664.70	2639 / 2642	100%	51.45	703 / 705
intestine	100%	6715.16	966 / 966	99%	34.67	524 / 527
breast	100%	6618.48	459 / 459	99%	56.52	1108 / 1118
pancreas	100%	4514.90	327 / 328	99%	26.14	176 / 178
skin	100%	6629.96	1809 / 1809	98%	41.48	464 / 472
bladder	100%	6706.43	21 / 21	98%	38.09	495 / 504
thymus	100%	6797.75	653 / 653	98%	37.71	593 / 605
prostate	100%	6522.31	245 / 245	98%	38.35	490 / 502
uterus	100%	8105.44	170 / 170	97%	44.96	447 / 459
kidney	100%	4706.80	89 / 89	95%	28.94	859 / 901
adrenal gland	100%	7165.20	258 / 258	86%	17.93	197 / 230
liver	100%	3066.29	226 / 226	81%	15.57	330 / 406
adipose	100%	5675.11	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5661.36	1335 / 1335	0%	0	0 / 0
spleen	100%	7198.65	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	13.00	1 / 1
muscle	100%	4462.50	802 / 803	0%	0	0 / 0
heart	98%	3724.34	840 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	42.22	28 / 29
tonsil	0%	0	0 / 0	96%	43.97	43 / 45
peripheral blood	91%	5206.87	843 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	89%	19.14	71 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1902455	Biological process	negative regulation of stem cell population maintenance
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_2000736	Biological process	regulation of stem cell differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006260	Biological process	DNA replication
GO_0006338	Biological process	chromatin remodeling
GO_0006334	Biological process	nucleosome assembly
GO_0042659	Biological process	regulation of cell fate specification
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0007420	Biological process	brain development
GO_0030336	Biological process	negative regulation of cell migration
GO_0006335	Biological process	DNA replication-dependent chromatin assembly
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0032991	Cellular component	protein-containing complex
GO_0070822	Cellular component	Sin3-type complex
GO_0005654	Cellular component	nucleoplasm
GO_0000118	Cellular component	histone deacetylase complex
GO_0035098	Cellular component	ESC/E(Z) complex
GO_0005829	Cellular component	cytosol
GO_1904949	Cellular component	ATPase complex
GO_0033186	Cellular component	CAF-1 complex
GO_0016581	Cellular component	NuRD complex
GO_0000781	Cellular component	chromosome, telomeric region
GO_0016589	Cellular component	NURF complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0042393	Molecular function	histone binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0008094	Molecular function	ATP-dependent activity, acting on DNA
GO_0005515	Molecular function	protein binding
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	RBBP4
Protein name	RB binding protein 4, chromatin remodeling factor Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Synonyms	RBAP48
Description	FUNCTION: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. .
Accessions	C9JPP3 H0YDK2 ENST00000527118.5 E9PNS2 ENST00000475321.5 Q09028 ENST00000458695.6 [Q09028-4] ENST00000477563.6 ENST00000373485.5 [Q09028-3] ENST00000482190.1 H0YCT5 ENST00000526193.5 ENST00000460669.5 E9PND5 ENST00000373493.10 [Q09028-1] H0YEU5 E9PIC4 ENST00000414241.7 [Q09028-2] ENST00000463378.5 ENST00000490500.5 ENST00000492348.6 H0YF10 ENST00000445722.2 E9PNS6

RBBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review