CBX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031507Biological processheterochromatin formation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0035097Cellular componenthistone methyltransferase complex
GO_0010369Cellular componentchromocenter
GO_0000792Cellular componentheterochromatin
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005635Cellular componentnuclear envelope
GO_0090734Cellular componentsite of DNA damage
GO_0000118Cellular componenthistone deacetylase complex
GO_0005721Cellular componentpericentric heterochromatin
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameCBX5
Protein nameCBX5 protein
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Chromobox 5
SynonymsHP1A
DescriptionFUNCTION: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. .

AccessionsF8VNY3
ENST00000550411.5
ENST00000209875.9
ENST00000552562.1
Q6I9T7
P45973
ENST00000439541.6