Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 34% ± 15% | |
| B cell | 22 studies | 22% ± 8% | |
| astrocyte | 15 studies | 44% ± 20% | |
| natural killer cell | 14 studies | 22% ± 7% | |
| glutamatergic neuron | 12 studies | 39% ± 24% | |
| oligodendrocyte | 12 studies | 35% ± 14% | |
| macrophage | 11 studies | 35% ± 15% | |
| microglial cell | 11 studies | 40% ± 14% | |
| CD16-positive, CD56-dim natural killer cell, human | 10 studies | 21% ± 5% | |
| GABAergic neuron | 10 studies | 41% ± 22% | |
| CD16-negative, CD56-bright natural killer cell, human | 10 studies | 23% ± 5% | |
| epithelial cell | 9 studies | 35% ± 15% | |
| oligodendrocyte precursor cell | 9 studies | 40% ± 14% | |
| memory B cell | 9 studies | 18% ± 3% | |
| naive B cell | 9 studies | 19% ± 2% | |
| adipocyte | 9 studies | 43% ± 12% | |
| fibroblast | 9 studies | 33% ± 9% | |
| CD8-positive, alpha-beta T cell | 8 studies | 20% ± 4% | |
| pericyte | 8 studies | 32% ± 15% | |
| myeloid cell | 8 studies | 28% ± 9% | |
| plasma cell | 8 studies | 34% ± 15% | |
| basal cell | 8 studies | 34% ± 16% | |
| mast cell | 7 studies | 25% ± 11% | |
| smooth muscle cell | 7 studies | 28% ± 9% | |
| T cell | 6 studies | 24% ± 8% | |
| CD4-positive, alpha-beta T cell | 6 studies | 21% ± 4% | |
| interneuron | 6 studies | 49% ± 19% | |
| dendritic cell | 6 studies | 28% ± 6% | |
| ciliated cell | 6 studies | 31% ± 9% | |
| endothelial cell of lymphatic vessel | 6 studies | 28% ± 10% | |
| neuron | 5 studies | 50% ± 18% | |
| retina horizontal cell | 5 studies | 24% ± 5% | |
| monocyte | 5 studies | 32% ± 9% | |
| club cell | 5 studies | 32% ± 12% | |
| type I pneumocyte | 5 studies | 37% ± 12% | |
| type II pneumocyte | 5 studies | 32% ± 10% | |
| regulatory T cell | 5 studies | 21% ± 6% | |
| effector memory CD8-positive, alpha-beta T cell | 4 studies | 22% ± 3% | |
| mature NK T cell | 4 studies | 23% ± 11% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 21% ± 5% | |
| granule cell | 4 studies | 29% ± 10% | |
| precursor B cell | 4 studies | 21% ± 4% | |
| cardiac muscle cell | 4 studies | 29% ± 4% | |
| lymphocyte | 4 studies | 34% ± 7% | |
| amacrine cell | 4 studies | 22% ± 1% | |
| retinal cone cell | 4 studies | 21% ± 7% | |
| retinal rod cell | 4 studies | 28% ± 6% | |
| respiratory goblet cell | 4 studies | 37% ± 16% | |
| abnormal cell | 4 studies | 29% ± 15% | |
| CD8-positive, alpha-beta memory T cell | 4 studies | 18% ± 2% | |
| gamma-delta T cell | 4 studies | 22% ± 8% | |
| non-classical monocyte | 3 studies | 21% ± 4% | |
| plasmablast | 3 studies | 30% ± 5% | |
| IgG plasma cell | 3 studies | 28% ± 3% | |
| GABAergic interneuron | 3 studies | 38% ± 13% | |
| glial cell | 3 studies | 28% ± 11% | |
| progenitor cell | 3 studies | 35% ± 8% | |
| mononuclear phagocyte | 3 studies | 24% ± 8% | |
| mucosal invariant T cell | 3 studies | 22% ± 5% | |
| vein endothelial cell | 3 studies | 32% ± 14% | |
| GABAergic amacrine cell | 3 studies | 20% ± 4% | |
| Mueller cell | 3 studies | 27% ± 3% | |
| glycinergic amacrine cell | 3 studies | 20% ± 4% | |
| germinal center B cell | 3 studies | 24% ± 8% | |
| endothelial cell of vascular tree | 3 studies | 29% ± 12% | |
| cholangiocyte | 3 studies | 51% ± 16% | |
| hepatocyte | 3 studies | 62% ± 19% | |
| retinal pigment epithelial cell | 3 studies | 35% ± 13% | |
| neural progenitor cell | 3 studies | 29% ± 10% | |
| ependymal cell | 3 studies | 42% ± 17% | |
| leukocyte | 3 studies | 23% ± 5% | |
| alveolar macrophage | 3 studies | 42% ± 12% | |
| muscle cell | 3 studies | 28% ± 14% | |
| goblet cell | 3 studies | 40% ± 28% | |
| brush cell | 3 studies | 20% ± 3% | |
| mucus secreting cell | 3 studies | 37% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 4703.24 | 459 / 459 | 100% | 12.11 | 1118 / 1118 |
| esophagus | 100% | 4113.27 | 1445 / 1445 | 100% | 12.51 | 183 / 183 |
| intestine | 100% | 4498.58 | 966 / 966 | 100% | 9.35 | 527 / 527 |
| prostate | 100% | 4873.44 | 245 / 245 | 100% | 10.47 | 502 / 502 |
| stomach | 100% | 3166.73 | 359 / 359 | 100% | 9.49 | 285 / 286 |
| bladder | 100% | 4345.62 | 21 / 21 | 100% | 9.05 | 502 / 504 |
| uterus | 100% | 4915.16 | 170 / 170 | 99% | 9.89 | 456 / 459 |
| thymus | 100% | 5002.78 | 653 / 653 | 99% | 9.16 | 600 / 605 |
| brain | 100% | 2565.80 | 2633 / 2642 | 99% | 8.86 | 700 / 705 |
| skin | 100% | 4272.34 | 1809 / 1809 | 99% | 7.77 | 467 / 472 |
| lung | 100% | 4127.44 | 577 / 578 | 99% | 9.14 | 1144 / 1155 |
| ovary | 100% | 4890.01 | 180 / 180 | 99% | 8.27 | 424 / 430 |
| pancreas | 100% | 1941.36 | 327 / 328 | 99% | 8.13 | 176 / 178 |
| kidney | 100% | 2776.27 | 89 / 89 | 97% | 5.66 | 875 / 901 |
| adrenal gland | 100% | 4506.67 | 258 / 258 | 93% | 5.56 | 215 / 230 |
| liver | 100% | 2472.96 | 226 / 226 | 91% | 4.55 | 370 / 406 |
| adipose | 100% | 4138.66 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.50 | 29 / 29 |
| muscle | 100% | 3563.96 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5989.01 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.35 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.10 | 1 / 1 |
| blood vessel | 100% | 3346.16 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2051.17 | 853 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 5.43 | 78 / 80 |
| peripheral blood | 96% | 3919.34 | 891 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0006346 | Biological process | DNA methylation-dependent heterochromatin formation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0018026 | Biological process | peptidyl-lysine monomethylation |
| GO_0060992 | Biological process | response to fungicide |
| GO_0018027 | Biological process | peptidyl-lysine dimethylation |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0046974 | Molecular function | histone H3K9 methyltransferase activity |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0046976 | Molecular function | histone H3K27 methyltransferase activity |
| GO_0140947 | Molecular function | histone H3K9me2 methyltransferase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0016279 | Molecular function | protein-lysine N-methyltransferase activity |
| GO_0002039 | Molecular function | p53 binding |
| GO_0008168 | Molecular function | methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0070742 | Molecular function | C2H2 zinc finger domain binding |
| Gene name | EHMT1 |
| Protein name | Euchromatic histone lysine methyltransferase 1 EHMT1 protein Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) |
| Synonyms | KMT1D EUHMTASE1 KIAA1876 GLP |
| Description | FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). . |
| Accessions | ENST00000460486.3 ENST00000626066.2 ENST00000626216.2 A0A1B0GTP4 ENST00000637949.1 ENST00000630754.2 A0A1B0GV89 A0A1B0GUD1 A0A0D9SER3 ENST00000371394.6 [Q9H9B1-2] A0A1B0GW79 A0A1B0GW12 ENST00000629808.2 A0A0D9SEY2 ENST00000486164.5 Q9H9B1 A0A0D9SFG7 A0A0D9SFD7 A0A0D9SFS4 ENST00000637161.1 A0A0D9SER9 ENST00000465566.2 ENST00000637891.1 A0A0D9SEQ1 ENST00000636027.1 ENST00000460843.6 [Q9H9B1-1] A0A1B0GWF6 ENST00000629417.1 ENST00000638071.1 ENST00000462484.5 [Q9H9B1-4] A0A0D9SEP2 A0A0D9SF38 ENST00000492232.5 ENST00000493484.5 ENST00000629335.2 ENST00000637977.1 A0A1B0GV09 A0A1B0GVZ8 A0PJE0 ENST00000462942.3 A0A1W2PPZ7 ENST00000637318.1 A0A0C4DGF8 ENST00000478940.1 ENST00000640639.1 A0A0D9SFX4 A0A0D9SFM6 ENST00000482340.5 A0A1B0GU48 ENST00000637261.1 |