EHMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045995Biological processregulation of embryonic development
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_0060992Biological processresponse to fungicide
GO_0018027Biological processpeptidyl-lysine dimethylation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0046976Molecular functionhistone H3K27 methyltransferase activity
GO_0140947Molecular functionhistone H3K9me2 methyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0002039Molecular functionp53 binding
GO_0008168Molecular functionmethyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0070742Molecular functionC2H2 zinc finger domain binding

IV. Literature review

[source]
Gene nameEHMT1
Protein nameEuchromatic histone lysine methyltransferase 1
EHMT1 protein
Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)
SynonymsKMT1D
EUHMTASE1
KIAA1876
GLP
DescriptionFUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). .

AccessionsENST00000460486.3
ENST00000626066.2
ENST00000626216.2
A0A1B0GTP4
ENST00000637949.1
ENST00000630754.2
A0A1B0GV89
A0A1B0GUD1
A0A0D9SER3
ENST00000371394.6 [Q9H9B1-2]
A0A1B0GW79
A0A1B0GW12
ENST00000629808.2
A0A0D9SEY2
ENST00000486164.5
Q9H9B1
A0A0D9SFG7
A0A0D9SFD7
A0A0D9SFS4
ENST00000637161.1
A0A0D9SER9
ENST00000465566.2
ENST00000637891.1
A0A0D9SEQ1
ENST00000636027.1
ENST00000460843.6 [Q9H9B1-1]
A0A1B0GWF6
ENST00000629417.1
ENST00000638071.1
ENST00000462484.5 [Q9H9B1-4]
A0A0D9SEP2
A0A0D9SF38
ENST00000492232.5
ENST00000493484.5
ENST00000629335.2
ENST00000637977.1
A0A1B0GV09
A0A1B0GVZ8
A0PJE0
ENST00000462942.3
A0A1W2PPZ7
ENST00000637318.1
A0A0C4DGF8
ENST00000478940.1
ENST00000640639.1
A0A0D9SFX4
A0A0D9SFM6
ENST00000482340.5
A0A1B0GU48
ENST00000637261.1