JDP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0045444Biological processfat cell differentiation
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0043522Molecular functionleucine zipper domain binding
GO_0140713Molecular functionhistone chaperone activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0035497Molecular functioncAMP response element binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameJDP2
Protein nameJun dimerization protein 2
Synonyms
DescriptionFUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. .

AccessionsENST00000435893.6 [Q8WYK2-1]
ENST00000651602.1 [Q8WYK2-1]
ENST00000267569.5 [Q8WYK2-2]
ENST00000559060.5
ENST00000419727.6 [Q8WYK2-1]
H0YKE4
Q8WYK2
ENST00000437176.5 [Q8WYK2-1]