Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 3 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of TFAP2C at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 86% | 1021.48 | 210 / 245 | 99% | 29.47 | 497 / 502 |
breast | 61% | 2578.72 | 282 / 459 | 98% | 78.79 | 1092 / 1118 |
skin | 94% | 4392.10 | 1703 / 1809 | 61% | 36.12 | 289 / 472 |
uterus | 34% | 519.86 | 58 / 170 | 86% | 45.25 | 395 / 459 |
esophagus | 43% | 1325.05 | 620 / 1445 | 69% | 40.23 | 127 / 183 |
thymus | 47% | 240.46 | 308 / 653 | 56% | 8.36 | 336 / 605 |
bladder | 29% | 222.00 | 6 / 21 | 72% | 25.35 | 364 / 504 |
tonsil | 0% | 0 | 0 / 0 | 98% | 47.85 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 98% | 42.82 | 78 / 80 |
lung | 13% | 61.40 | 78 / 578 | 82% | 30.99 | 947 / 1155 |
ovary | 1% | 4.76 | 2 / 180 | 88% | 38.77 | 377 / 430 |
intestine | 41% | 298.63 | 395 / 966 | 21% | 3.69 | 113 / 527 |
pancreas | 3% | 13.45 | 10 / 328 | 22% | 4.49 | 39 / 178 |
stomach | 1% | 2.90 | 2 / 359 | 20% | 3.50 | 58 / 286 |
adrenal gland | 0% | 0 | 0 / 258 | 16% | 6.92 | 37 / 230 |
adipose | 15% | 83.71 | 180 / 1204 | 0% | 0 | 0 / 0 |
kidney | 6% | 35.18 | 5 / 89 | 7% | 1.26 | 61 / 901 |
liver | 0% | 0 | 0 / 226 | 2% | 0.47 | 9 / 406 |
brain | 0% | 0.44 | 3 / 2642 | 2% | 0.42 | 14 / 705 |
muscle | 0% | 1.20 | 2 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 0% | 3.04 | 2 / 1335 | 0% | 0 | 0 / 0 |
heart | 0% | 1.02 | 1 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045814 | Biological process | negative regulation of gene expression, epigenetic |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0007267 | Biological process | cell-cell signaling |
GO_0008584 | Biological process | male gonad development |
GO_0048856 | Biological process | anatomical structure development |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005739 | Cellular component | mitochondrion |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TFAP2C |
Protein name | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) Transcription factor AP-2 gamma |
Synonyms | |
Description | FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. . |
Accessions | ENST00000201031.3 [Q92754-1] Q92754 A2A2R7 ENST00000416606.1 |