MBD3 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	5 studies	26% ± 9%	Explore
endothelial cell	3 studies	20% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MBD3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5022.55	1445 / 1445	100%	16.32	183 / 183
brain	100%	6431.70	2639 / 2642	100%	37.95	705 / 705
thymus	100%	6192.70	653 / 653	100%	24.31	604 / 605
adrenal gland	100%	5391.30	258 / 258	100%	24.26	229 / 230
uterus	100%	5958.13	170 / 170	100%	28.02	457 / 459
prostate	100%	7075.04	245 / 245	99%	27.77	499 / 502
liver	100%	3938.67	226 / 226	99%	17.20	402 / 406
skin	100%	5055.16	1809 / 1809	99%	27.87	467 / 472
kidney	100%	5120.12	89 / 89	99%	17.66	889 / 901
bladder	100%	5090.71	21 / 21	99%	23.39	497 / 504
breast	100%	4666.63	459 / 459	98%	18.02	1100 / 1118
pancreas	100%	2557.42	328 / 328	98%	18.25	175 / 178
ovary	100%	5769.55	180 / 180	98%	14.45	422 / 430
intestine	100%	4934.99	966 / 966	98%	19.14	515 / 527
lung	100%	4953.36	576 / 578	97%	17.63	1122 / 1155
stomach	100%	4001.72	359 / 359	93%	15.78	267 / 286
adipose	100%	4829.25	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	35.23	80 / 80
lymph node	0%	0	0 / 0	100%	34.06	29 / 29
muscle	100%	5353.55	803 / 803	0%	0	0 / 0
spleen	100%	6265.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.79	45 / 45
ureter	0%	0	0 / 0	100%	26.35	1 / 1
blood vessel	100%	4387.05	1333 / 1335	0%	0	0 / 0
heart	100%	4505.88	858 / 861	0%	0	0 / 0
peripheral blood	90%	2597.31	834 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0032355	Biological process	response to estradiol
GO_0048568	Biological process	embryonic organ development
GO_0001701	Biological process	in utero embryonic development
GO_2000736	Biological process	regulation of stem cell differentiation
GO_0006346	Biological process	DNA methylation-dependent heterochromatin formation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0031667	Biological process	response to nutrient levels
GO_0042659	Biological process	regulation of cell fate specification
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0003229	Biological process	ventricular cardiac muscle tissue development
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0000792	Cellular component	heterochromatin
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0016581	Cellular component	NuRD complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0008327	Molecular function	methyl-CpG binding
GO_0005515	Molecular function	protein binding

Gene name	MBD3
Protein name	Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) Methyl-CpG binding domain protein 3
Synonyms	hCG_22692
Description	FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Acts as transcriptional repressor and plays a role in gene silencing . Does not bind to methylated DNA by itself . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides . Recruits histone deacetylases and DNA methyltransferases. .
Accessions	ENST00000592965.2 ENST00000585967.5 A0A087WT34 ENST00000592361.2 ENST00000585903.1 ENST00000590550.6 K7EIE8 A0A087X1H1 ENST00000156825.5 [O95983-2] ENST00000592012.5 ENST00000434436.8 [O95983-1] A0A087WVG6 O95983 A0A0A0MTS6 A0A087WZ12

MBD3 report