CBX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031519Cellular componentPcG protein complex
GO_0000792Cellular componentheterochromatin
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0035102Cellular componentPRC1 complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0005515Molecular functionprotein binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameCBX6
Protein nameChromobox protein homolog 6
Chromobox 6
Synonyms
DescriptionFUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin . Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). .

AccessionsO95503
ENST00000216083.6
ENST00000407418.8
B0QXZ6