Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 21 studies | 29% ± 14% | |
| fibroblast | 16 studies | 26% ± 10% | |
| pericyte | 16 studies | 26% ± 8% | |
| plasmacytoid dendritic cell | 12 studies | 26% ± 8% | |
| conventional dendritic cell | 8 studies | 25% ± 9% | |
| myofibroblast cell | 8 studies | 30% ± 10% | |
| glutamatergic neuron | 7 studies | 36% ± 17% | |
| connective tissue cell | 6 studies | 26% ± 10% | |
| endothelial cell | 6 studies | 31% ± 8% | |
| dendritic cell | 5 studies | 32% ± 21% | |
| monocyte | 5 studies | 23% ± 7% | |
| neuron | 5 studies | 32% ± 14% | |
| amacrine cell | 5 studies | 33% ± 13% | |
| GABAergic neuron | 5 studies | 31% ± 14% | |
| pancreatic A cell | 4 studies | 53% ± 16% | |
| CD4-positive, alpha-beta T cell | 4 studies | 18% ± 2% | |
| classical monocyte | 4 studies | 28% ± 12% | |
| epithelial cell | 4 studies | 37% ± 7% | |
| natural killer cell | 3 studies | 22% ± 3% | |
| pancreatic D cell | 3 studies | 53% ± 18% | |
| type B pancreatic cell | 3 studies | 43% ± 21% | |
| naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 20% ± 5% | |
| retinal bipolar neuron | 3 studies | 26% ± 5% | |
| pancreatic ductal cell | 3 studies | 38% ± 10% | |
| enteroendocrine cell | 3 studies | 44% ± 22% | |
| basal cell | 3 studies | 39% ± 13% | |
| ciliated cell | 3 studies | 40% ± 14% | |
| oligodendrocyte | 3 studies | 21% ± 3% | |
| interneuron | 3 studies | 32% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 6346.92 | 652 / 653 | 100% | 62.53 | 604 / 605 |
| prostate | 100% | 7149.48 | 244 / 245 | 100% | 38.72 | 502 / 502 |
| brain | 100% | 13473.09 | 2640 / 2642 | 99% | 62.75 | 701 / 705 |
| kidney | 100% | 4994.21 | 89 / 89 | 99% | 44.80 | 888 / 901 |
| adrenal gland | 100% | 6607.02 | 258 / 258 | 96% | 61.26 | 220 / 230 |
| breast | 98% | 3994.06 | 449 / 459 | 93% | 31.27 | 1045 / 1118 |
| lung | 99% | 5440.61 | 574 / 578 | 91% | 35.47 | 1050 / 1155 |
| pancreas | 92% | 2921.90 | 303 / 328 | 96% | 32.33 | 171 / 178 |
| uterus | 99% | 9299.78 | 168 / 170 | 85% | 28.29 | 390 / 459 |
| ovary | 99% | 7210.56 | 179 / 180 | 84% | 20.51 | 362 / 430 |
| skin | 83% | 3320.76 | 1506 / 1809 | 100% | 63.11 | 470 / 472 |
| esophagus | 93% | 8616.74 | 1350 / 1445 | 85% | 24.12 | 156 / 183 |
| bladder | 100% | 9310.86 | 21 / 21 | 77% | 22.18 | 390 / 504 |
| stomach | 97% | 5286.11 | 350 / 359 | 70% | 18.73 | 199 / 286 |
| intestine | 95% | 8232.04 | 920 / 966 | 65% | 13.66 | 343 / 527 |
| blood vessel | 100% | 10160.26 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 43.65 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 40.70 | 29 / 29 |
| spleen | 100% | 4851.25 | 240 / 241 | 0% | 0 | 0 / 0 |
| adipose | 98% | 4036.49 | 1179 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 41.56 | 44 / 45 |
| heart | 93% | 3401.06 | 805 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 3827.87 | 752 / 929 | 0% | 0 | 0 / 0 |
| liver | 22% | 484.25 | 49 / 226 | 43% | 9.25 | 174 / 406 |
| muscle | 52% | 1080.76 | 417 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0000792 | Cellular component | heterochromatin |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0035102 | Cellular component | PRC1 complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0035064 | Molecular function | methylated histone binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003727 | Molecular function | single-stranded RNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | CBX6 |
| Protein name | Chromobox protein homolog 6 Chromobox 6 |
| Synonyms | |
| Description | FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin . Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). . |
| Accessions | O95503 ENST00000216083.6 ENST00000407418.8 B0QXZ6 |