ETV3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ETV3 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0008150Biological processbiological_process
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0090571Cellular componentRNA polymerase II transcription repressor complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0017151Molecular functionDEAD/H-box RNA helicase binding

IV. Literature review

[source]
Gene nameETV3
Protein nameETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)
SynonymsMETS
PE1
DescriptionFUNCTION: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. .

AccessionsP41162
ENST00000326786.4 [P41162-2]
ENST00000368192.9 [P41162-1]