TRIM37 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0016558Biological processprotein import into peroxisome matrix
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0051865Biological processprotein autoubiquitination
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0046600Biological processnegative regulation of centriole replication
GO_0050821Biological processprotein stabilization
GO_0070842Biological processaggresome assembly
GO_0006513Biological processprotein monoubiquitination
GO_0005778Cellular componentperoxisomal membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005777Cellular componentperoxisome
GO_0035098Cellular componentESC/E(Z) complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0016235Cellular componentaggresome
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0003682Molecular functionchromatin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0140862Molecular functionhistone H2AK119 ubiquitin ligase activity

IV. Literature review

[source]
Gene nameTRIM37
Protein nameE3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Tripartite motif containing 37
SynonymsPOB1
KIAA0898
MUL
DescriptionFUNCTION: E3 ubiquitin-protein ligase required to prevent centriole reduplication . Probably acts by ubiquitinating positive regulators of centriole reduplication . Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes . Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome . Has anti-HIV activity . .

AccessionsJ3KS72
J3QRK3
J3KT32
ENST00000625984.1
J3QSF6
J3QSA0
ENST00000580973.5
ENST00000262294.12 [O94972-1]
ENST00000581468.1
ENST00000577554.5
ENST00000585287.5
ENST00000583945.5
J3QSH5
ENST00000393065.6 [O94972-3]
ENST00000580122.5
ENST00000393066.7 [O94972-1]
ENST00000584889.3
J3KT90
O94972