HDAC10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HDAC10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HDAC10 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006281Biological processDNA repair
GO_0032425Biological processpositive regulation of mismatch repair
GO_0016236Biological processmacroautophagy
GO_0106047Biological processpolyamine deacetylation
GO_0106048Biological processspermidine deacetylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035825Biological processhomologous recombination
GO_0006355Biological processregulation of DNA-templated transcription
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0019213Molecular functiondeacetylase activity
GO_0004407Molecular functionhistone deacetylase activity
GO_0047609Molecular functionacetylputrescine deacetylase activity
GO_0008270Molecular functionzinc ion binding
GO_0047611Molecular functionacetylspermidine deacetylase activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC10
Protein namePolyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10)
HDAC10 protein (Histone deacetylase 10)
Histone deacetylase 10
Synonyms
DescriptionFUNCTION: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine . Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine . Histone deacetylase activity has been observed in vitro . Has also been shown to be involved in MSH2 deacetylation . The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak . May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells . May play a role in homologous recombination . May promote DNA mismatch repair . .

AccessionsENST00000454936.5 [Q969S8-5]
ENST00000415993.5
Q969S8
ENST00000626012.2
Q08AP5
ENST00000448072.5
ENST00000429374.5
C9J8B8
ENST00000349505.4 [Q969S8-2]
ENST00000216271.10 [Q969S8-1]