TFEC | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	23 studies	29% ± 13%	Explore
classical monocyte	11 studies	23% ± 8%	Explore
myeloid cell	9 studies	30% ± 14%	Explore
microglial cell	9 studies	36% ± 16%	Explore
alveolar macrophage	6 studies	35% ± 18%	Explore
monocyte	6 studies	27% ± 6%	Explore
conventional dendritic cell	5 studies	21% ± 6%	Explore
dendritic cell	5 studies	25% ± 5%	Explore
mononuclear phagocyte	4 studies	25% ± 9%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TFEC at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	98%	1304.45	87 / 89	90%	16.72	809 / 901
lung	100%	2094.96	577 / 578	81%	3.66	940 / 1155
breast	93%	345.64	425 / 459	87%	3.82	976 / 1118
intestine	97%	522.96	937 / 966	44%	1.27	233 / 527
bladder	90%	254.62	19 / 21	43%	1.40	219 / 504
esophagus	70%	168.98	1018 / 1445	54%	1.70	99 / 183
stomach	62%	127.80	223 / 359	61%	2.16	174 / 286
thymus	72%	188.56	468 / 653	49%	1.25	294 / 605
brain	40%	97.32	1055 / 2642	74%	2.54	521 / 705
adrenal gland	96%	407.57	248 / 258	17%	0.28	40 / 230
ovary	44%	87.41	79 / 180	64%	1.75	274 / 430
pancreas	37%	75.45	122 / 328	70%	3.37	125 / 178
uterus	59%	101.90	101 / 170	45%	1.18	208 / 459
prostate	76%	176.16	187 / 245	26%	0.50	133 / 502
spleen	100%	1930.37	241 / 241	0%	0	0 / 0
adipose	98%	700.77	1185 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	14.26	28 / 29
peripheral blood	83%	432.05	769 / 929	0%	0	0 / 0
blood vessel	81%	310.41	1088 / 1335	0%	0	0 / 0
skin	26%	41.35	470 / 1809	53%	2.22	252 / 472
liver	46%	87.53	104 / 226	23%	0.53	93 / 406
tonsil	0%	0	0 / 0	67%	2.35	30 / 45
heart	57%	122.84	493 / 861	0%	0	0 / 0
muscle	13%	18.27	106 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	8%	0.13	6 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0034605	Biological process	cellular response to heat
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0046983	Molecular function	protein dimerization activity

Gene name	TFEC
Protein name	Uncharacterized protein TFEC Transcription factor EC Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L)
Synonyms	TFECL BHLHE34 TCFEC
Description	FUNCTION: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. .
Accessions	ENST00000457268.5 [O14948-4] ENST00000484212.5 Q75KY0 ENST00000265440.12 [O14948-1] B7Z757 O14948 Q75MG2 ENST00000393485.5 [O14948-3] ENST00000320239.11 [O14948-2]

TFEC report