ZBTB18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007519Biological processskeletal muscle tissue development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000792Cellular componentheterochromatin
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZBTB18
Protein nameZinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)
Zinc finger and BTB domain containing 18
SynonymsTAZ1
RP58
ZNF238
DescriptionFUNCTION: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. .

AccessionsENST00000696616.1 [Q99592-1]
A0A8V8TM03
ENST00000698634.1
Q99592
ENST00000696615.1
A0A8Q3WLX6
ENST00000358704.4 [Q99592-2]
ENST00000622512.1 [Q99592-1]
ENST00000696618.1 [Q99592-1]
ENST00000696617.1
A0A8Q3WLD9