NACC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0008285Biological processnegative regulation of cell population proliferation
GO_1902231Biological processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031503Biological processprotein-containing complex localization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameNACC2
Protein nameNucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain)
SynonymsBTBD14A
NAC2
RBB
DescriptionFUNCTION: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. .

AccessionsENST00000277554.4
ENST00000371753.5
Q96BF6