E2F6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameE2F6
Protein nameE2F transcription factor 6 (Putative truncated transcription factor E2F6)
Transcription factor E2F6 (E2F-6)
E2F transcription factor 6, isoform CRA_d (E2F6 splice variant c) (E2F6 splice variant d) (E2F6 splice variant e) (cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6)
E2F transcription factor 6
E2F transcription factor 6 isoform 1 (E2F transcription factor 6, isoform CRA_c)
E2F6 splice variant f
E2F6 splice variant a
SynonymshCG_1989492
DescriptionFUNCTION: Inhibitor of E2F-dependent transcription . Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' . Has a preference for the 5'-TTTCCCGC-3' E2F recognition site . E2F6 lacks the transcriptional activation and pocket protein binding domains . Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression . Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase . .

AccessionsF8WEZ5
ENST00000307236.8 [O75461-3]
ENST00000542100.5 [O75461-2]
A0A0S2Z3K8
Q6Q9Z7
ENST00000421117.1
ENST00000444832.5
Q2Z197
ENST00000455198.5
O75461
ENST00000546212.2 [O75461-2]
F8WC40
ENST00000428221.5
Q6Q9Z5
Q2Z196
Q53YM3
ENST00000437573.5
ENST00000381525.8 [O75461-1]