PRDM14 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRDM14 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRDM14 at tissue level.

III. Associated gene sets

GO_0001708Biological processcell fate specification
GO_0032259Biological processmethylation
GO_1902093Biological processpositive regulation of flagellated sperm motility
GO_0001827Biological processinner cell mass cell fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0048873Biological processhomeostasis of number of cells within a tissue
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0009566Biological processfertilization
GO_0007281Biological processgerm cell development
GO_0000902Biological processcell morphogenesis
GO_0040029Biological processepigenetic regulation of gene expression
GO_0030718Biological processgerm-line stem cell population maintenance
GO_0040037Biological processnegative regulation of fibroblast growth factor receptor signaling pathway
GO_0007566Biological processembryo implantation
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0008168Molecular functionmethyltransferase activity
GO_0003723Molecular functionRNA binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRDM14
Protein namePR/SET domain 14
PR domain-containing 14
PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)
Synonyms
DescriptionFUNCTION: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. .

AccessionsC9JMM8
ENST00000426346.1
ENST00000276594.3
A0A023UFG1
Q9GZV8