CBX8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CBX8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBX8 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045739Biological processpositive regulation of DNA repair
GO_0031519Cellular componentPcG protein complex
GO_0000792Cellular componentheterochromatin
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0097027Molecular functionubiquitin-protein transferase activator activity
GO_0005515Molecular functionprotein binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameCBX8
Protein nameChromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Chromobox 8
SynonymsRC1
PC3
DescriptionFUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. .

AccessionsENST00000427800.2
ENST00000413392.5
Q9HC52
ENST00000269385.9
C9J6K3
C9JM54