HES5 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HES5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	93%	309.60	2466 / 2642	93%	30.67	659 / 705
ureter	0%	0	0 / 0	100%	3.90	1 / 1
skin	69%	170.38	1245 / 1809	8%	0.25	39 / 472
bladder	52%	46.95	11 / 21	24%	0.80	122 / 504
esophagus	27%	15.18	390 / 1445	41%	1.24	75 / 183
heart	65%	75.85	556 / 861	0%	0	0 / 0
uterus	20%	11.47	34 / 170	39%	1.46	180 / 459
tonsil	0%	0	0 / 0	56%	1.88	25 / 45
intestine	24%	12.23	230 / 966	24%	0.80	128 / 527
blood vessel	47%	52.92	624 / 1335	0%	0	0 / 0
thymus	34%	27.35	221 / 653	10%	0.18	63 / 605
prostate	34%	23.08	84 / 245	4%	0.08	21 / 502
lung	17%	15.56	97 / 578	13%	0.38	154 / 1155
breast	23%	15.04	106 / 459	5%	0.10	61 / 1118
stomach	4%	1.63	15 / 359	22%	0.71	64 / 286
adipose	23%	16.05	278 / 1204	0%	0	0 / 0
kidney	4%	1.72	4 / 89	18%	0.45	160 / 901
liver	7%	3.98	16 / 226	5%	0.08	20 / 406
ovary	3%	1.59	6 / 180	4%	0.08	16 / 430
spleen	6%	5.63	15 / 241	0%	0	0 / 0
adrenal gland	0%	0.25	1 / 258	6%	0.09	13 / 230
pancreas	0%	0.10	1 / 328	6%	0.12	10 / 178
peripheral blood	6%	3.84	55 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.16	4 / 80
muscle	1%	0.46	10 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_2000974	Biological process	negative regulation of pro-B cell differentiation
GO_0014003	Biological process	oligodendrocyte development
GO_0031641	Biological process	regulation of myelination
GO_0048715	Biological process	negative regulation of oligodendrocyte differentiation
GO_0007224	Biological process	smoothened signaling pathway
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0007219	Biological process	Notch signaling pathway
GO_0090162	Biological process	establishment of epithelial cell polarity
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0002062	Biological process	chondrocyte differentiation
GO_0042491	Biological process	inner ear auditory receptor cell differentiation
GO_0060122	Biological process	inner ear receptor cell stereocilium organization
GO_0007155	Biological process	cell adhesion
GO_0048712	Biological process	negative regulation of astrocyte differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048708	Biological process	astrocyte differentiation
GO_0022010	Biological process	central nervous system myelination
GO_0065003	Biological process	protein-containing complex assembly
GO_0021861	Biological process	forebrain radial glial cell differentiation
GO_0030509	Biological process	BMP signaling pathway
GO_0072050	Biological process	S-shaped body morphogenesis
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0072086	Biological process	specification of loop of Henle identity
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0045595	Biological process	regulation of cell differentiation
GO_0021781	Biological process	glial cell fate commitment
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0045608	Biological process	negative regulation of inner ear auditory receptor cell differentiation
GO_2000737	Biological process	negative regulation of stem cell differentiation
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0072282	Biological process	metanephric nephron tubule morphogenesis
GO_0007420	Biological process	brain development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0043010	Biological process	camera-type eye development
GO_0050767	Biological process	regulation of neurogenesis
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0021915	Biological process	neural tube development
GO_0048469	Biological process	cell maturation
GO_0051216	Biological process	cartilage development
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_2000978	Biological process	negative regulation of forebrain neuron differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0021537	Biological process	telencephalon development
GO_0072049	Biological process	comma-shaped body morphogenesis
GO_0005575	Cellular component	cellular_component
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0046983	Molecular function	protein dimerization activity

Gene name	HES5
Protein name	HES5 protein Transcription factor HES-5 (Class B basic helix-loop-helix protein 38) (bHLHb38) (Hairy and enhancer of split 5)
Synonyms	BHLHB38
Description	FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). .
Accessions	Q5M8T3 ENST00000378453.4 Q5TA89 ENST00000612705.2

HES5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review