BPTF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	36% ± 16%	Explore
B cell	36 studies	33% ± 11%	Explore
fibroblast	34 studies	32% ± 13%	Explore
natural killer cell	32 studies	31% ± 12%	Explore
pericyte	28 studies	30% ± 13%	Explore
smooth muscle cell	26 studies	29% ± 11%	Explore
T cell	25 studies	29% ± 11%	Explore
macrophage	25 studies	29% ± 13%	Explore
CD8-positive, alpha-beta T cell	22 studies	28% ± 9%	Explore
astrocyte	21 studies	46% ± 18%	Explore
CD4-positive, alpha-beta T cell	21 studies	27% ± 10%	Explore
regulatory T cell	21 studies	26% ± 8%	Explore
mast cell	20 studies	31% ± 12%	Explore
memory B cell	19 studies	25% ± 9%	Explore
ciliated cell	19 studies	39% ± 15%	Explore
naive B cell	19 studies	31% ± 12%	Explore
endothelial cell of lymphatic vessel	17 studies	40% ± 16%	Explore
oligodendrocyte precursor cell	16 studies	52% ± 18%	Explore
gamma-delta T cell	16 studies	31% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	32% ± 12%	Explore
classical monocyte	15 studies	26% ± 11%	Explore
oligodendrocyte	15 studies	54% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	31% ± 13%	Explore
mature NK T cell	15 studies	27% ± 11%	Explore
epithelial cell	15 studies	41% ± 22%	Explore
basal cell	14 studies	38% ± 17%	Explore
plasmacytoid dendritic cell	14 studies	29% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	29% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	26% ± 12%	Explore
myofibroblast cell	13 studies	28% ± 12%	Explore
microglial cell	13 studies	46% ± 13%	Explore
mucosal invariant T cell	13 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	31% ± 10%	Explore
glutamatergic neuron	12 studies	53% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	34% ± 13%	Explore
capillary endothelial cell	12 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	23% ± 8%	Explore
conventional dendritic cell	11 studies	29% ± 17%	Explore
dendritic cell	10 studies	37% ± 17%	Explore
monocyte	10 studies	32% ± 12%	Explore
type I pneumocyte	10 studies	37% ± 12%	Explore
non-classical monocyte	10 studies	26% ± 10%	Explore
GABAergic neuron	10 studies	54% ± 21%	Explore
connective tissue cell	10 studies	29% ± 11%	Explore
endothelial cell of artery	10 studies	24% ± 5%	Explore
vein endothelial cell	10 studies	28% ± 14%	Explore
myeloid cell	10 studies	36% ± 8%	Explore
adipocyte	9 studies	44% ± 14%	Explore
type II pneumocyte	8 studies	35% ± 9%	Explore
progenitor cell	8 studies	33% ± 13%	Explore
abnormal cell	8 studies	37% ± 16%	Explore
neuron	8 studies	50% ± 21%	Explore
mesothelial cell	8 studies	35% ± 15%	Explore
amacrine cell	8 studies	45% ± 8%	Explore
retinal rod cell	8 studies	37% ± 15%	Explore
club cell	8 studies	38% ± 13%	Explore
endothelial cell of vascular tree	8 studies	30% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	21% ± 7%	Explore
leukocyte	7 studies	44% ± 11%	Explore
interneuron	7 studies	64% ± 18%	Explore
retinal ganglion cell	7 studies	34% ± 11%	Explore
hematopoietic stem cell	7 studies	36% ± 17%	Explore
retinal cone cell	7 studies	45% ± 9%	Explore
respiratory goblet cell	6 studies	37% ± 15%	Explore
secretory cell	6 studies	29% ± 10%	Explore
lymphocyte	6 studies	44% ± 16%	Explore
precursor B cell	6 studies	38% ± 12%	Explore
retina horizontal cell	6 studies	50% ± 9%	Explore
Mueller cell	6 studies	41% ± 13%	Explore
T follicular helper cell	6 studies	23% ± 7%	Explore
innate lymphoid cell	6 studies	31% ± 11%	Explore
hematopoietic precursor cell	5 studies	41% ± 15%	Explore
mononuclear phagocyte	5 studies	25% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	25% ± 9%	Explore
retinal bipolar neuron	5 studies	48% ± 9%	Explore
glial cell	5 studies	40% ± 13%	Explore
pro-B cell	5 studies	32% ± 9%	Explore
plasma cell	5 studies	34% ± 12%	Explore
brush cell	5 studies	35% ± 15%	Explore
immature B cell	5 studies	36% ± 10%	Explore
cardiac muscle cell	5 studies	40% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 12%	Explore
goblet cell	5 studies	36% ± 21%	Explore
alveolar macrophage	5 studies	36% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	25% ± 9%	Explore
exhausted T cell	4 studies	29% ± 16%	Explore
plasmablast	4 studies	38% ± 22%	Explore
renal alpha-intercalated cell	4 studies	26% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	48% ± 18%	Explore
granule cell	4 studies	54% ± 3%	Explore
retinal pigment epithelial cell	4 studies	45% ± 19%	Explore
muscle cell	4 studies	35% ± 23%	Explore
enteroendocrine cell	4 studies	32% ± 10%	Explore
double negative thymocyte	4 studies	36% ± 15%	Explore
ionocyte	3 studies	39% ± 12%	Explore
pancreatic A cell	3 studies	30% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
glomerular endothelial cell	3 studies	21% ± 1%	Explore
neural crest cell	3 studies	32% ± 2%	Explore
GABAergic interneuron	3 studies	56% ± 8%	Explore
squamous epithelial cell	3 studies	41% ± 24%	Explore
GABAergic amacrine cell	3 studies	50% ± 11%	Explore
OFF-bipolar cell	3 studies	52% ± 7%	Explore
ON-bipolar cell	3 studies	53% ± 9%	Explore
glycinergic amacrine cell	3 studies	46% ± 11%	Explore
rod bipolar cell	3 studies	55% ± 5%	Explore
erythroblast	3 studies	36% ± 8%	Explore
germinal center B cell	3 studies	34% ± 3%	Explore
CD4-positive helper T cell	3 studies	33% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	22% ± 6%	Explore
myoepithelial cell	3 studies	37% ± 15%	Explore
hepatocyte	3 studies	57% ± 18%	Explore
neural progenitor cell	3 studies	55% ± 8%	Explore
adventitial cell	3 studies	26% ± 6%	Explore
chondrocyte	3 studies	35% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 15%	Explore
Schwann cell	3 studies	39% ± 17%	Explore
melanocyte	3 studies	40% ± 22%	Explore
transit amplifying cell	3 studies	40% ± 31%	Explore
T-helper 17 cell	3 studies	22% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	25% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 9%	Explore
kidney loop of Henle epithelial cell	3 studies	28% ± 9%	Explore
renal principal cell	3 studies	29% ± 8%	Explore
mural cell	3 studies	54% ± 13%	Explore
mucus secreting cell	3 studies	38% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	52% ± 19%	Explore
lung	16 studies	30% ± 11%	Explore
peripheral blood	14 studies	29% ± 14%	Explore
eye	10 studies	41% ± 15%	Explore
kidney	7 studies	28% ± 9%	Explore
intestine	7 studies	25% ± 11%	Explore
heart	5 studies	34% ± 9%	Explore
liver	5 studies	40% ± 15%	Explore
bone marrow	4 studies	33% ± 14%	Explore
lymph node	4 studies	25% ± 8%	Explore
adipose	4 studies	45% ± 18%	Explore
placenta	3 studies	22% ± 6%	Explore
uterus	3 studies	42% ± 16%	Explore
breast	3 studies	28% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4524.66	1445 / 1445	100%	30.94	183 / 183
brain	100%	4855.50	2638 / 2642	99%	23.55	701 / 705
breast	100%	5612.24	459 / 459	99%	29.80	1108 / 1118
lung	100%	4658.46	578 / 578	99%	18.92	1138 / 1155
ovary	100%	7518.38	180 / 180	98%	16.19	423 / 430
intestine	100%	5290.51	966 / 966	98%	15.53	518 / 527
thymus	100%	5918.39	653 / 653	98%	17.30	593 / 605
pancreas	99%	2420.28	326 / 328	98%	14.47	175 / 178
bladder	100%	4719.00	21 / 21	98%	15.28	492 / 504
prostate	100%	5059.66	245 / 245	98%	18.31	490 / 502
stomach	100%	3586.53	359 / 359	98%	19.13	279 / 286
uterus	100%	7276.02	170 / 170	96%	15.01	442 / 459
skin	100%	6243.18	1809 / 1809	95%	20.21	450 / 472
kidney	100%	3606.90	89 / 89	93%	15.11	836 / 901
adrenal gland	100%	4248.13	258 / 258	87%	11.41	200 / 230
liver	98%	1693.53	222 / 226	67%	6.56	271 / 406
adipose	100%	5192.65	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4999.20	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	15.58	29 / 29
muscle	100%	3252.32	803 / 803	0%	0	0 / 0
spleen	100%	4863.85	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.89	1 / 1
heart	96%	2643.03	825 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	14.93	43 / 45
eye	0%	0	0 / 0	89%	12.84	71 / 80
peripheral blood	84%	3267.92	783 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001892	Biological process	embryonic placenta development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0007492	Biological process	endoderm development
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0007420	Biological process	brain development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0030425	Cellular component	dendrite
GO_0005737	Cellular component	cytoplasm
GO_0044297	Cellular component	cell body
GO_1904949	Cellular component	ATPase complex
GO_0016589	Cellular component	NURF complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0046872	Molecular function	metal ion binding
GO_0008094	Molecular function	ATP-dependent activity, acting on DNA
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BPTF
Protein name	BPTF protein Bromodomain PHD finger transcription factor Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)
Synonyms	FALZ FAC1
Description	FUNCTION: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex . Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development . Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes . Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent . May also regulate transcription through direct binding to DNA or transcription factors . .
Accessions	J3KSK9 E7ETD6 ENST00000321892.8 [Q12830-1] F5H176 F5GXF5 ENST00000581258.5 J3KSY0 ENST00000424123.7 ENST00000544491.2 ENST00000644067.1 ENST00000544778.6 ENST00000577837.1 A0A2R8Y7Q1 ENST00000582467.2 ENST00000580465.5 Q12830 J3QQK4 E9PE19 Q86TN2 ENST00000583990.1 ENST00000306378.11 [Q12830-2] J3QLW4 J3QQQ8 ENST00000342579.8

BPTF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review