Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 29 studies | 34% ± 13% | |
| astrocyte | 16 studies | 40% ± 20% | |
| oligodendrocyte precursor cell | 12 studies | 35% ± 18% | |
| microglial cell | 12 studies | 35% ± 13% | |
| oligodendrocyte | 11 studies | 34% ± 12% | |
| glutamatergic neuron | 10 studies | 40% ± 27% | |
| macrophage | 10 studies | 34% ± 16% | |
| GABAergic neuron | 9 studies | 47% ± 21% | |
| capillary endothelial cell | 9 studies | 25% ± 11% | |
| pericyte | 9 studies | 30% ± 14% | |
| fibroblast | 9 studies | 30% ± 13% | |
| endothelial cell of lymphatic vessel | 8 studies | 41% ± 19% | |
| B cell | 7 studies | 23% ± 7% | |
| adipocyte | 7 studies | 27% ± 6% | |
| neuron | 6 studies | 43% ± 21% | |
| interneuron | 6 studies | 50% ± 24% | |
| epithelial cell | 6 studies | 33% ± 16% | |
| dendritic cell | 6 studies | 22% ± 3% | |
| mast cell | 6 studies | 25% ± 6% | |
| smooth muscle cell | 6 studies | 22% ± 4% | |
| cardiac muscle cell | 5 studies | 32% ± 8% | |
| ciliated cell | 5 studies | 24% ± 7% | |
| myeloid cell | 5 studies | 24% ± 4% | |
| monocyte | 5 studies | 25% ± 7% | |
| type I pneumocyte | 5 studies | 24% ± 7% | |
| type II pneumocyte | 5 studies | 23% ± 7% | |
| granule cell | 4 studies | 23% ± 4% | |
| vein endothelial cell | 4 studies | 41% ± 22% | |
| Mueller cell | 4 studies | 27% ± 12% | |
| retinal rod cell | 4 studies | 26% ± 6% | |
| endothelial cell of vascular tree | 4 studies | 35% ± 22% | |
| T cell | 4 studies | 20% ± 3% | |
| club cell | 4 studies | 27% ± 10% | |
| endothelial cell of artery | 3 studies | 19% ± 4% | |
| GABAergic interneuron | 3 studies | 37% ± 7% | |
| glial cell | 3 studies | 25% ± 7% | |
| progenitor cell | 3 studies | 28% ± 4% | |
| CD4-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
| retinal cone cell | 3 studies | 30% ± 12% | |
| hepatocyte | 3 studies | 44% ± 19% | |
| connective tissue cell | 3 studies | 22% ± 8% | |
| ependymal cell | 3 studies | 36% ± 23% | |
| alveolar macrophage | 3 studies | 28% ± 9% | |
| natural killer cell | 3 studies | 19% ± 2% | |
| lymphocyte | 3 studies | 31% ± 11% | |
| basal cell | 3 studies | 35% ± 19% | |
| goblet cell | 3 studies | 41% ± 29% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 918.33 | 1445 / 1445 | 100% | 9.59 | 183 / 183 |
| prostate | 100% | 973.45 | 245 / 245 | 100% | 6.91 | 502 / 502 |
| brain | 100% | 1000.13 | 2640 / 2642 | 100% | 18.87 | 705 / 705 |
| adrenal gland | 100% | 2372.74 | 258 / 258 | 100% | 12.37 | 229 / 230 |
| breast | 100% | 1120.02 | 459 / 459 | 100% | 9.55 | 1113 / 1118 |
| kidney | 100% | 1034.93 | 89 / 89 | 99% | 8.41 | 894 / 901 |
| thymus | 100% | 1535.67 | 653 / 653 | 99% | 8.15 | 600 / 605 |
| lung | 100% | 1883.13 | 578 / 578 | 98% | 6.82 | 1137 / 1155 |
| skin | 100% | 1093.66 | 1808 / 1809 | 98% | 10.29 | 464 / 472 |
| pancreas | 100% | 619.80 | 327 / 328 | 98% | 6.57 | 175 / 178 |
| uterus | 100% | 1360.13 | 170 / 170 | 97% | 6.90 | 447 / 459 |
| stomach | 100% | 756.52 | 359 / 359 | 97% | 7.00 | 278 / 286 |
| ovary | 100% | 1284.21 | 180 / 180 | 96% | 5.98 | 413 / 430 |
| bladder | 100% | 1043.90 | 21 / 21 | 95% | 5.70 | 481 / 504 |
| intestine | 100% | 952.56 | 966 / 966 | 94% | 5.61 | 498 / 527 |
| liver | 100% | 645.12 | 226 / 226 | 78% | 3.00 | 318 / 406 |
| adipose | 100% | 1121.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 11.57 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 6.99 | 29 / 29 |
| spleen | 100% | 1435.49 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.60 | 1 / 1 |
| blood vessel | 100% | 829.55 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 530.16 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 781.08 | 854 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 6.83 | 44 / 45 |
| peripheral blood | 91% | 739.32 | 844 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051972 | Biological process | regulation of telomerase activity |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0051973 | Biological process | positive regulation of telomerase activity |
| GO_0035563 | Biological process | positive regulation of chromatin binding |
| GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005813 | Cellular component | centrosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0016605 | Cellular component | PML body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0015030 | Cellular component | Cajal body |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042162 | Molecular function | telomeric DNA binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0003691 | Molecular function | double-stranded telomeric DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HMBOX1 |
| Protein name | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) Homeobox containing 1 |
| Synonyms | TAH1 HOT1 |
| Description | FUNCTION: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination . Might also be involved in the DNA damage response at telomeres . . |
| Accessions | E5RGZ2 ENST00000287701.15 [Q6NT76-1] ENST00000560599.5 ENST00000522468.1 Q6NT76 ENST00000524238.3 [Q6NT76-5] H0YBM8 ENST00000521516.5 [Q6NT76-4] ENST00000558662.5 [Q6NT76-2] ENST00000523613.5 H0YKJ1 H0YLF2 E5RHH9 ENST00000355231.9 ENST00000519047.5 ENST00000519662.5 ENST00000397358.7 [Q6NT76-1] |