HMBOX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051972Biological processregulation of telomerase activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051973Biological processpositive regulation of telomerase activity
GO_0035563Biological processpositive regulation of chromatin binding
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0043565Molecular functionsequence-specific DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003691Molecular functiondouble-stranded telomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHMBOX1
Protein nameHomeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1)
Homeobox containing 1
SynonymsTAH1
HOT1
DescriptionFUNCTION: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination . Might also be involved in the DNA damage response at telomeres . .

AccessionsE5RGZ2
ENST00000287701.15 [Q6NT76-1]
ENST00000560599.5
ENST00000522468.1
Q6NT76
ENST00000524238.3 [Q6NT76-5]
H0YBM8
ENST00000521516.5 [Q6NT76-4]
ENST00000558662.5 [Q6NT76-2]
ENST00000523613.5
H0YKJ1
H0YLF2
E5RHH9
ENST00000355231.9
ENST00000519047.5
ENST00000519662.5
ENST00000397358.7 [Q6NT76-1]