HNRNPA2B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050658Biological processRNA transport
GO_0006397Biological processmRNA processing
GO_1990428Biological processmiRNA transport
GO_0051028Biological processmRNA transport
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_0044806Biological processG-quadruplex DNA unwinding
GO_1904358Biological processpositive regulation of telomere maintenance via telomere lengthening
GO_1905663Biological processpositive regulation of telomerase RNA reverse transcriptase activity
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0031053Biological processprimary miRNA processing
GO_0005681Cellular componentspliceosomal complex
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0000781Cellular componentchromosome, telomeric region
GO_1990904Cellular componentribonucleoprotein complex
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0043047Molecular functionsingle-stranded telomeric DNA binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHNRNPA2B1
Protein nameHeterogeneous nuclear ribonucleoprotein A2/B1
Heterogeneous nuclear ribonucleoproteins A2/B1
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
SynonymsHNRPA2B1
hCG_38388
DescriptionFUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs . Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm . Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts . Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs . Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs . Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform . Also plays a role in the activation of the innate immune response . Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 . In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production . .; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. .

AccessionsENST00000678884.1 [P22626-2]
ENST00000678431.1 [P22626-2]
ENST00000676903.1 [P22626-2]
ENST00000677656.1 [P22626-2]
ENST00000678962.1 [P22626-2]
A0A7I2V3P1
ENST00000618183.5 [P22626-2]
ENST00000354667.8 [P22626-1]
A0A087WUI2
ENST00000677574.1 [P22626-2]
ENST00000676749.1 [P22626-2]
ENST00000679021.1 [P22626-1]
ENST00000678501.1 [P22626-2]
ENST00000677631.1 [P22626-2]
ENST00000678183.1
ENST00000677321.1
ENST00000678675.1 [P22626-1]
ENST00000678631.1
ENST00000678035.1
ENST00000618183
ENST00000677839.1 [P22626-2]
ENST00000676746.1 [P22626-1]
ENST00000356674.8 [P22626-1]
ENST00000678779.1 [P22626-2]
ENST00000676497.1 [P22626-2]
ENST00000679001.1 [P22626-1]
ENST00000679124.1
A0A7I2V4I6
ENST00000608362.2 [P22626-2]
A0A7I2YQN4
I6L957
A0A7I2V3P7
A0A7I2V4S4
ENST00000360787.8 [P22626-1]
ENST00000677906.1 [P22626-2]
ENST00000678935.1 [P22626-2]
A0A7I2V323
ENST00000678697.1 [P22626-2]
ENST00000678998.1 [P22626-2]
ENST00000678449.1 [P22626-2]
ENST00000679243.1 [P22626-2]
A0A7I2V4N0
ENST00000676524.1 [P22626-2]
ENST00000678075.1
ENST00000677339.1 [P22626-2]
ENST00000678973.1
ENST00000679123.1 [P22626-1]
P22626
ENST00000679318.1 [P22626-2]
ENST00000677571.1
ENST00000677037.1
ENST00000678277.1
A0A7I2V4N1
ENST00000677396.1 [P22626-2]
A0A024RA28