IMPACT | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1545.37	245 / 245	100%	36.26	502 / 502
breast	100%	1894.05	459 / 459	100%	40.99	1116 / 1118
esophagus	100%	1309.77	1445 / 1445	99%	29.60	182 / 183
thymus	100%	1979.25	653 / 653	99%	30.12	600 / 605
ovary	100%	1697.99	180 / 180	99%	18.09	426 / 430
pancreas	99%	982.15	326 / 328	99%	21.12	176 / 178
lung	99%	1212.35	573 / 578	99%	30.34	1142 / 1155
adrenal gland	100%	2432.79	258 / 258	98%	23.82	225 / 230
uterus	100%	1530.98	170 / 170	98%	22.31	448 / 459
kidney	100%	1344.35	89 / 89	97%	23.41	878 / 901
bladder	100%	1567.19	21 / 21	96%	18.22	486 / 504
brain	99%	1561.47	2623 / 2642	96%	31.74	678 / 705
intestine	100%	1274.38	966 / 966	95%	18.13	501 / 527
skin	100%	1991.13	1807 / 1809	95%	27.85	448 / 472
stomach	100%	1045.98	359 / 359	94%	17.04	270 / 286
liver	100%	1009.03	226 / 226	89%	12.64	360 / 406
adipose	100%	1733.16	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1797.65	1335 / 1335	0%	0	0 / 0
spleen	100%	1065.07	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	16.06	1 / 1
muscle	98%	877.28	788 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	27.71	44 / 45
heart	93%	893.65	804 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	18.54	73 / 80
lymph node	0%	0	0 / 0	66%	6.66	19 / 29
peripheral blood	46%	286.51	424 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0034198	Biological process	cellular response to amino acid starvation
GO_0140469	Biological process	GCN2-mediated signaling
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_1990138	Biological process	neuron projection extension
GO_1990611	Biological process	regulation of cytoplasmic translational initiation in response to stress
GO_0035556	Biological process	intracellular signal transduction
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0006446	Biological process	regulation of translational initiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0008150	Biological process	biological_process
GO_0005575	Cellular component	cellular_component
GO_0005737	Cellular component	cytoplasm
GO_0043022	Molecular function	ribosome binding
GO_0140311	Molecular function	protein sequestering activity
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0003674	Molecular function	molecular_function

Gene name	IMPACT
Protein name	Impact RWD domain protein Protein IMPACT (Imprinted and ancient gene protein homolog) IMPACT Protein IMPACT
Synonyms
Description	FUNCTION: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. .
Accessions	ENST00000580035.1 J3KT25 ENST00000578221.1 J3QRS6 Q5GFE0 A0A3B3ITH3 ENST00000585067.5 J3QLU6 ENST00000648078.1 J3QQU0 Q9P2X3 ENST00000581278.1 ENST00000284202.9 [Q9P2X3-1]

IMPACT report