CNOT2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	31% ± 13%	Explore
natural killer cell	28 studies	26% ± 7%	Explore
fibroblast	21 studies	27% ± 10%	Explore
B cell	18 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	18 studies	22% ± 6%	Explore
oligodendrocyte	16 studies	40% ± 17%	Explore
CD4-positive, alpha-beta T cell	16 studies	22% ± 7%	Explore
T cell	15 studies	21% ± 6%	Explore
oligodendrocyte precursor cell	15 studies	34% ± 16%	Explore
astrocyte	15 studies	35% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	26% ± 9%	Explore
macrophage	14 studies	31% ± 14%	Explore
regulatory T cell	14 studies	20% ± 4%	Explore
naive B cell	13 studies	20% ± 4%	Explore
pericyte	13 studies	24% ± 9%	Explore
microglial cell	13 studies	41% ± 12%	Explore
smooth muscle cell	13 studies	23% ± 5%	Explore
glutamatergic neuron	12 studies	41% ± 25%	Explore
memory B cell	12 studies	19% ± 3%	Explore
gamma-delta T cell	12 studies	27% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
epithelial cell	11 studies	35% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
GABAergic neuron	10 studies	44% ± 21%	Explore
mature NK T cell	10 studies	23% ± 6%	Explore
capillary endothelial cell	10 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	10 studies	23% ± 7%	Explore
adipocyte	10 studies	28% ± 9%	Explore
classical monocyte	9 studies	22% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	25% ± 7%	Explore
mucosal invariant T cell	9 studies	22% ± 4%	Explore
basal cell	8 studies	32% ± 18%	Explore
ciliated cell	8 studies	27% ± 10%	Explore
interneuron	7 studies	47% ± 22%	Explore
myeloid cell	7 studies	27% ± 7%	Explore
mast cell	7 studies	22% ± 6%	Explore
dendritic cell	7 studies	32% ± 15%	Explore
endothelial cell of lymphatic vessel	7 studies	28% ± 10%	Explore
monocyte	7 studies	26% ± 8%	Explore
non-classical monocyte	6 studies	28% ± 11%	Explore
conventional dendritic cell	6 studies	27% ± 15%	Explore
abnormal cell	6 studies	29% ± 14%	Explore
neuron	6 studies	43% ± 16%	Explore
club cell	6 studies	25% ± 9%	Explore
myofibroblast cell	6 studies	28% ± 9%	Explore
endothelial cell of artery	6 studies	19% ± 2%	Explore
endothelial cell of vascular tree	6 studies	25% ± 16%	Explore
type II pneumocyte	6 studies	23% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	22% ± 5%	Explore
leukocyte	5 studies	32% ± 9%	Explore
connective tissue cell	5 studies	23% ± 7%	Explore
retinal bipolar neuron	5 studies	29% ± 13%	Explore
pro-B cell	5 studies	25% ± 6%	Explore
amacrine cell	5 studies	32% ± 10%	Explore
retina horizontal cell	5 studies	29% ± 12%	Explore
retinal rod cell	5 studies	25% ± 8%	Explore
vein endothelial cell	5 studies	27% ± 15%	Explore
innate lymphoid cell	5 studies	25% ± 9%	Explore
type I pneumocyte	5 studies	25% ± 8%	Explore
goblet cell	5 studies	32% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	20% ± 3%	Explore
hematopoietic precursor cell	4 studies	29% ± 14%	Explore
mononuclear phagocyte	4 studies	26% ± 8%	Explore
glial cell	4 studies	28% ± 8%	Explore
granule cell	4 studies	40% ± 9%	Explore
progenitor cell	4 studies	30% ± 7%	Explore
retinal ganglion cell	4 studies	26% ± 13%	Explore
precursor B cell	4 studies	30% ± 7%	Explore
immature B cell	4 studies	24% ± 8%	Explore
cardiac muscle cell	4 studies	20% ± 1%	Explore
lymphocyte	4 studies	38% ± 15%	Explore
Mueller cell	4 studies	28% ± 12%	Explore
T follicular helper cell	4 studies	21% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 8%	Explore
exhausted T cell	3 studies	28% ± 6%	Explore
plasmablast	3 studies	36% ± 14%	Explore
GABAergic interneuron	3 studies	31% ± 1%	Explore
retinal cone cell	3 studies	23% ± 6%	Explore
mesothelial cell	3 studies	27% ± 8%	Explore
GABAergic amacrine cell	3 studies	38% ± 10%	Explore
OFF-bipolar cell	3 studies	37% ± 12%	Explore
ON-bipolar cell	3 studies	42% ± 15%	Explore
glycinergic amacrine cell	3 studies	39% ± 9%	Explore
rod bipolar cell	3 studies	35% ± 11%	Explore
hepatocyte	3 studies	49% ± 21%	Explore
neural progenitor cell	3 studies	36% ± 8%	Explore
ependymal cell	3 studies	38% ± 16%	Explore
hematopoietic stem cell	3 studies	22% ± 7%	Explore
enteroendocrine cell	3 studies	22% ± 6%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
adventitial cell	3 studies	18% ± 4%	Explore
respiratory goblet cell	3 studies	26% ± 6%	Explore
alveolar macrophage	3 studies	32% ± 10%	Explore
chondrocyte	3 studies	28% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 9%	Explore
Schwann cell	3 studies	31% ± 16%	Explore
transit amplifying cell	3 studies	39% ± 31%	Explore
double negative thymocyte	3 studies	35% ± 12%	Explore
mural cell	3 studies	33% ± 14%	Explore
mucus secreting cell	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	38% ± 21%	Explore
peripheral blood	11 studies	25% ± 9%	Explore
lung	11 studies	24% ± 8%	Explore
eye	7 studies	31% ± 16%	Explore
kidney	4 studies	20% ± 2%	Explore
bone marrow	4 studies	20% ± 4%	Explore
heart	4 studies	20% ± 3%	Explore
liver	4 studies	34% ± 16%	Explore
intestine	4 studies	23% ± 9%	Explore
adipose	4 studies	25% ± 6%	Explore
uterus	3 studies	22% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	3625.24	21 / 21	100%	16.49	504 / 504
breast	100%	4191.62	459 / 459	100%	21.23	1118 / 1118
esophagus	100%	3032.22	1445 / 1445	100%	18.86	183 / 183
lung	100%	4304.50	578 / 578	100%	17.02	1155 / 1155
ovary	100%	3851.48	180 / 180	100%	17.07	430 / 430
prostate	100%	3612.78	245 / 245	100%	13.67	502 / 502
thymus	100%	3869.11	653 / 653	100%	15.87	605 / 605
uterus	100%	4232.16	170 / 170	100%	16.51	459 / 459
intestine	100%	3694.74	966 / 966	100%	15.55	526 / 527
stomach	100%	2440.22	359 / 359	100%	15.34	285 / 286
brain	99%	2888.04	2620 / 2642	100%	18.13	705 / 705
adrenal gland	100%	2968.43	258 / 258	99%	11.33	228 / 230
kidney	100%	2699.98	89 / 89	99%	13.61	893 / 901
liver	100%	1951.58	226 / 226	99%	8.38	402 / 406
pancreas	100%	1852.23	327 / 328	99%	14.79	176 / 178
skin	100%	5501.25	1809 / 1809	98%	15.06	462 / 472
adipose	100%	3992.68	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4062.63	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.92	29 / 29
muscle	100%	2467.83	803 / 803	0%	0	0 / 0
spleen	100%	4205.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.30	45 / 45
ureter	0%	0	0 / 0	100%	5.47	1 / 1
heart	98%	1938.59	841 / 861	0%	0	0 / 0
peripheral blood	95%	2407.73	881 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	9.49	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001829	Biological process	trophectodermal cell differentiation
GO_0010606	Biological process	positive regulation of cytoplasmic mRNA processing body assembly
GO_2000036	Biological process	regulation of stem cell population maintenance
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0033147	Biological process	negative regulation of intracellular estrogen receptor signaling pathway
GO_0006417	Biological process	regulation of translation
GO_0031047	Biological process	regulatory ncRNA-mediated gene silencing
GO_0000289	Biological process	nuclear-transcribed mRNA poly(A) tail shortening
GO_0030015	Cellular component	CCR4-NOT core complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0000932	Cellular component	P-body
GO_0030014	Cellular component	CCR4-NOT complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0001222	Molecular function	transcription corepressor binding
GO_0003712	Molecular function	transcription coregulator activity
GO_0004535	Molecular function	poly(A)-specific ribonuclease activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CNOT2
Protein name	CCR4-NOT transcription complex subunit 2 CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)
Synonyms	HSPC131 CDC36 MSTP046 NOT2
Description	FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. .
Accessions	ENST00000551710.1 F8VV05 ENST00000550194.5 ENST00000548159.5 ENST00000546673.5 A0A087X050 H0YHT6 F8VPX5 ENST00000547867.5 ENST00000552151.2 F8VS14 F8VQD8 ENST00000550641.6 ENST00000552599.5 ENST00000418359.7 [Q9NZN8-1] ENST00000550160.5 F8VUB4 F8VWH8 ENST00000548599.5 F8VVY1 F8VRJ3 ENST00000551483.5 [Q9NZN8-3] ENST00000551132.5 ENST00000552915.5 F8VQF4 F8VX63 H0YH84 ENST00000551661.5 ENST00000549750.5 ENST00000229195.8 [Q9NZN8-1] F8VRS8 ENST00000551043.5 [Q9NZN8-1] ENST00000552483.5 H0YI11 F8W145 ENST00000548741.5 ENST00000548338.5 ENST00000549709.5 F8VSK9 ENST00000547780.5 Q9NZN8 ENST00000552319.5 H0YI80 F8VVD4 ENST00000553020.5 H0YHT8 F8VV52 ENST00000551873.5

CNOT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review