HOPX | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	40 studies	62% ± 17%	Explore
CD8-positive, alpha-beta T cell	27 studies	36% ± 12%	Explore
mature NK T cell	20 studies	55% ± 17%	Explore
T cell	19 studies	28% ± 10%	Explore
gamma-delta T cell	19 studies	48% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	61% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	70% ± 16%	Explore
mucosal invariant T cell	13 studies	35% ± 11%	Explore
CD4-positive, alpha-beta T cell	13 studies	24% ± 10%	Explore
type I pneumocyte	12 studies	76% ± 21%	Explore
type II pneumocyte	12 studies	66% ± 28%	Explore
astrocyte	11 studies	25% ± 6%	Explore
epithelial cell	10 studies	34% ± 22%	Explore
innate lymphoid cell	9 studies	42% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	35% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	39% ± 12%	Explore
endothelial cell	8 studies	34% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	51% ± 18%	Explore
hematopoietic stem cell	6 studies	48% ± 14%	Explore
club cell	6 studies	49% ± 26%	Explore
glutamatergic neuron	6 studies	35% ± 18%	Explore
B cell	5 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	42% ± 16%	Explore
pericyte	5 studies	31% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	25% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
fibroblast	5 studies	24% ± 10%	Explore
keratinocyte	5 studies	46% ± 15%	Explore
squamous epithelial cell	4 studies	56% ± 16%	Explore
pancreatic A cell	4 studies	25% ± 5%	Explore
type B pancreatic cell	4 studies	48% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	28% ± 10%	Explore
smooth muscle cell	4 studies	25% ± 12%	Explore
basal cell	4 studies	26% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	51% ± 18%	Explore
hematopoietic precursor cell	3 studies	44% ± 20%	Explore
leukocyte	3 studies	20% ± 5%	Explore
myofibroblast cell	3 studies	26% ± 8%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
ciliated cell	3 studies	19% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	18% ± 4%	Explore
T-helper 1 cell	3 studies	29% ± 3%	Explore
memory B cell	3 studies	19% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	12 studies	22% ± 7%	Explore
peripheral blood	11 studies	22% ± 4%	Explore
brain	4 studies	31% ± 12%	Explore
pancreas	3 studies	28% ± 10%	Explore
liver	3 studies	20% ± 4%	Explore
skin	3 studies	27% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	98%	8665.28	637 / 653	94%	96.25	571 / 605
lung	98%	18838.74	567 / 578	82%	80.57	944 / 1155
brain	69%	5071.17	1812 / 2642	91%	65.25	640 / 705
esophagus	37%	10661.42	535 / 1445	63%	22.01	116 / 183
pancreas	0%	0	0 / 328	89%	24.13	159 / 178
skin	72%	45672.06	1300 / 1809	8%	1.87	39 / 472
bladder	14%	439.76	3 / 21	57%	24.12	289 / 504
tonsil	0%	0	0 / 0	64%	21.93	29 / 45
prostate	13%	571.69	32 / 245	47%	5.74	234 / 502
uterus	4%	495.05	6 / 170	44%	10.69	202 / 459
stomach	11%	360.75	38 / 359	35%	5.62	101 / 286
ovary	1%	42.82	2 / 180	39%	5.80	168 / 430
intestine	7%	241.51	67 / 966	28%	5.91	149 / 527
lymph node	0%	0	0 / 0	31%	17.74	9 / 29
adrenal gland	16%	788.32	41 / 258	10%	2.61	24 / 230
breast	0%	0	0 / 459	25%	3.11	283 / 1118
heart	19%	826.28	163 / 861	0%	0	0 / 0
kidney	4%	161.16	4 / 89	11%	1.22	99 / 901
liver	0%	0	0 / 226	6%	0.80	25 / 406
peripheral blood	5%	178.33	44 / 929	0%	0	0 / 0
blood vessel	2%	99.06	25 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.16	1 / 80
spleen	1%	21.84	2 / 241	0%	0	0 / 0
adipose	1%	44.21	7 / 1204	0%	0	0 / 0
muscle	0%	14.76	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001829	Biological process	trophectodermal cell differentiation
GO_0045596	Biological process	negative regulation of cell differentiation
GO_0051155	Biological process	positive regulation of striated muscle cell differentiation
GO_1903598	Biological process	positive regulation of gap junction assembly
GO_0048286	Biological process	lung alveolus development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0008016	Biological process	regulation of heart contraction
GO_0003166	Biological process	bundle of His development
GO_0043415	Biological process	positive regulation of skeletal muscle tissue regeneration
GO_0051131	Biological process	chaperone-mediated protein complex assembly
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0035033	Molecular function	histone deacetylase regulator activity
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HOPX
Protein name	Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1)
Synonyms	HOP HOD OB1 NECC1 LAGY
Description	FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding . .
Accessions	ENST00000556614.6 [Q9BPY8-1] Q9BPY8 ENST00000381260.7 [Q9BPY8-2] ENST00000420433.6 [Q9BPY8-3] ENST00000554144.5 [Q9BPY8-4] ENST00000317745.11 [Q9BPY8-1] ENST00000508121.2 [Q9BPY8-1] ENST00000555760.6 [Q9BPY8-1] ENST00000503639.7 [Q9BPY8-1] ENST00000381255.7 [Q9BPY8-1] ENST00000553379.6 [Q9BPY8-1] ENST00000556376.6 [Q9BPY8-1] ENST00000337881.12 [Q9BPY8-1]

HOPX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review