TDG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045995Biological processregulation of embryonic development
GO_0006285Biological processbase-excision repair, AP site formation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045008Biological processdepyrimidination
GO_0006284Biological processbase-excision repair
GO_0040029Biological processepigenetic regulation of gene expression
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0003677Molecular functionDNA binding
GO_0043739Molecular functionG/U mismatch-specific uracil-DNA glycosylase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019104Molecular functionDNA N-glycosylase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0031404Molecular functionchloride ion binding
GO_0003676Molecular functionnucleic acid binding
GO_0004844Molecular functionuracil DNA N-glycosylase activity
GO_0008263Molecular functionpyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0030983Molecular functionmismatched DNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0141016Molecular functionG/T mismatch-specific thymine-DNA glycosylase activity
GO_0032183Molecular functionSUMO binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0031402Molecular functionsodium ion binding

IV. Literature review

[source]
Gene nameTDG
Protein nameTDG protein
Thymine DNA glycosylase
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)
Synonyms
DescriptionFUNCTION: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. .

AccessionsENST00000540956.1
H0YH18
Q3SX60
ENST00000544861.5
F5H539
Q13569
ENST00000392872.8
ENST00000266775.13
G8JL98
B4E127
ENST00000537100.5
Q05CX8
F5H0I7
ENST00000436021.6