PCGF1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PCGF1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PCGF1 at tissue level.

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0006355Biological processregulation of DNA-templated transcription
GO_0031519Cellular componentPcG protein complex
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePCGF1
Protein namePolycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
SynonymsNSPC1
RNF68
DescriptionFUNCTION: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells . .

AccessionsENST00000233630.11 [Q9BSM1-1]
Q9BSM1