E4F1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of E4F1 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0009794Biological processregulation of mitotic cell cycle, embryonic
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051301Biological processcell division
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006260Biological processDNA replication
GO_0010564Biological processregulation of cell cycle process
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0016740Molecular functiontransferase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0035497Molecular functioncAMP response element binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE4F1
Protein nameE4F1 protein
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
E4F transcription factor 1
SynonymsE4F
DescriptionFUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.

AccessionsENST00000564139.5
H3BSL4
ENST00000565090.5
ENST00000562589.5
Q9BV18
H3BUJ7
H3BQZ4
ENST00000301727.9
Q66K89
ENST00000565413.1
H3BN24