PHF19 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PHF19 at tissue level.

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0048863Biological processstem cell differentiation
GO_0019827Biological processstem cell population maintenance
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035098Cellular componentESC/E(Z) complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePHF19
Protein namePHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
PHD finger protein 19
SynonymsPCL3
DescriptionFUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity . Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing . Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) . Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter . .

AccessionsENST00000616568.5
ENST00000436309.5
ENST00000456291.1
A0A087X169
ENST00000312189.10 [Q5T6S3-2]
ENST00000453868.5
ENST00000439674.1
ENST00000419155.5
B0QZ51
B0QZ72
Q5T6S3
ENST00000373896.8 [Q5T6S3-1]
F5H8K3
B0QZ50
X6RER8