NEUROG3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NEUROG3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEUROG3 at tissue level.

III. Associated gene sets

GO_0061564Biological processaxon development
GO_0021510Biological processspinal cord development
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0030855Biological processepithelial cell differentiation
GO_0030900Biological processforebrain development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007422Biological processperipheral nervous system development
GO_0007417Biological processcentral nervous system development
GO_0030902Biological processhindbrain development
GO_0060290Biological processtransdifferentiation
GO_0007399Biological processnervous system development
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0007423Biological processsensory organ development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0031490Molecular functionchromatin DNA binding
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEUROG3
Protein nameNeurogenin 3
Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)
SynonymsATOH5
NGN3
BHLHA7
DescriptionFUNCTION: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). .

AccessionsQ9Y4Z2
E0X9P2
ENST00000242462.5