TBX21 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBX21 at tissue level.

III. Associated gene sets

GO_0072676Biological processlymphocyte migration
GO_2000556Biological processpositive regulation of T-helper 1 cell cytokine production
GO_0001708Biological processcell fate specification
GO_0045580Biological processregulation of T cell differentiation
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009615Biological processresponse to virus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2000552Biological processnegative regulation of T-helper 2 cell cytokine production
GO_0002296Biological processT-helper 1 cell lineage commitment
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048304Biological processpositive regulation of isotype switching to IgG isotypes
GO_2000329Biological processnegative regulation of T-helper 17 cell lineage commitment
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043025Cellular componentneuronal cell body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBX21
Protein nameT-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
SynonymsTBLYM
TBET
DescriptionFUNCTION: Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs . Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG . Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells . Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity). Required for the correct development of natural killer (NK) and mucosal-associated invariant T (MAIT) cells . .

AccessionsQ9UL17
ENST00000177694.2