FOSB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0043278Biological processresponse to morphine
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032870Biological processcellular response to hormone stimulus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045471Biological processresponse to ethanol
GO_0007565Biological processfemale pregnancy
GO_0071277Biological processcellular response to calcium ion
GO_0051591Biological processresponse to cAMP
GO_0001975Biological processresponse to amphetamine
GO_0009612Biological processresponse to mechanical stimulus
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0048148Biological processbehavioral response to cocaine
GO_0051412Biological processresponse to corticosterone
GO_0032570Biological processresponse to progesterone
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOSB
Protein nameFOSB protein
FosB proto-oncogene, AP-1 transcription factor subunit
Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)
SynonymsG0S3
DescriptionFUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity . As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway . Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). .; FUNCTION: [Isoform 11]: Exhibits lower transactivation activity than isoform 1 in vitro (By similarity). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (By similarity). May be involved in the regulation of neurogenesis in the hippocampus (By similarity). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (By similarity). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (By similarity). .

AccessionsENST00000590335.1
ENST00000417353.6 [P53539-2]
ENST00000443841.6 [P53539-8]
Q6FGK6
K7EJ89
ENST00000585836.5 [P53539-5]
K7EKA0
P53539
K7ERZ8
ENST00000591858.5 [P53539-3]
ENST00000589593.1
ENST00000592436.5 [P53539-11]
ENST00000586615.5 [P53539-10]
A1L186
ENST00000592811.5
ENST00000353609.8 [P53539-1]