HEXIM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HEXIM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HEXIM2 at tissue level.

III. Associated gene sets

GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017069Molecular functionsnRNA binding
GO_0097322Molecular function7SK snRNA binding
GO_0004861Molecular functioncyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHEXIM2
Protein nameProtein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)
Protein HEXIM2
SynonymsL3
DescriptionFUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor . Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . .

AccessionsK7ELS4
ENST00000589230.6
ENST00000307275.7
ENST00000591576.5
ENST00000589230
K7EJA3
ENST00000586681.6
Q96MH2
K7ESM2
ENST00000593138
ENST00000593138.6
K7ERG7
K7EIM4
ENST00000586681
ENST00000585340
ENST00000585340.2
ENST00000592695.1
ENST00000591070.6
ENST00000591070