PDX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDX1 at tissue level.

III. Associated gene sets

GO_0003309Biological processtype B pancreatic cell differentiation
GO_0006366Biological processtranscription by RNA polymerase II
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0007224Biological processsmoothened signaling pathway
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0010157Biological processresponse to chlorate
GO_0070542Biological processresponse to fatty acid
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0034097Biological processresponse to cytokine
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0010040Biological processresponse to iron(II) ion
GO_0043279Biological processresponse to alkaloid
GO_0043201Biological processresponse to L-leucine
GO_2000675Biological processnegative regulation of type B pancreatic cell apoptotic process
GO_0001889Biological processliver development
GO_0031017Biological processexocrine pancreas development
GO_0031100Biological processanimal organ regeneration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0032024Biological processpositive regulation of insulin secretion
GO_0016331Biological processmorphogenesis of embryonic epithelium
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0033273Biological processresponse to vitamin
GO_0051384Biological processresponse to glucocorticoid
GO_0097050Biological processtype B pancreatic cell apoptotic process
GO_0035094Biological processresponse to nicotine
GO_0048565Biological processdigestive tract development
GO_0030073Biological processinsulin secretion
GO_1904692Biological processpositive regulation of type B pancreatic cell proliferation
GO_0060290Biological processtransdifferentiation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0048863Biological processstem cell differentiation
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0006006Biological processglucose metabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010255Biological processglucose mediated signaling pathway
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene namePDX1
Protein namePancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)
SynonymsSTF1
IPF1
DescriptionFUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

AccessionsP52945
ENST00000381033.5