ZGPAT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZGPAT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZGPAT at tissue level.

III. Associated gene sets

GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZGPAT
Protein nameZinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)
Zinc finger CCCH-type and G-patch domain containing
Zinc finger CCCH-type with G patch domain-containing protein
SynonymsGPATCH6
ZIP
ZC3H9
KIAA1847
ZC3HDC9
GPATC6
DescriptionFUNCTION: Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. .; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. .

AccessionsENST00000328969.5 [Q8N5A5-1]
A0A0S2Z5X3
A0A0S2Z6H0
ENST00000369967.7 [Q8N5A5-2]
ENST00000431125.1
X6RGY1
ENST00000448100.6 [Q8N5A5-2]
ENST00000355969.11 [Q8N5A5-2]
Q8N5A5
ENST00000357119.8 [Q8N5A5-3]